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Martorell hypertensive ischemic leg ulcer is a severe type of skin necrosis (skin infarction) which occurs in long-term hypertensive subjects.
Calciphylaxis (calcific uremic arteriolopathy) is a severe type of skin necrosis (skin infarction) which occurs in subjects with end-stage kidney disease or after kidney transplantation.
Comparative study including
The following parameters are measured in the blood serum:
White blood count; c-reactive protein; creatinine; calcium (total); free (ionized) calcium; phosphate; albumin; 25-hydroxyvitamin-D; 1-25-dihydroxyvitamin-D; homocysteine; cystatin C alphafetoin, osteoprotegerin; fibroblast growth factor 23 (FGF-23); globular arrest 1 (GLA-1)
The following parameters are measured in samples of diseased (necrobiotic) skin:
alphafetoin, osteoprotegerin; fibroblast growth factor 23 (FGF-23); globular arrest 1 (GLA-1)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hypertensive ischemic leg ulcer | Twenty consecutive patients with Martorell HYTILU as defined in: Arch Dermatol 2010;146:961-968 | ||
| Calciphylaxis | Ten subjects with calciphylaxis (calcific uremic arteriolopathy) as described in: Vasa 1998;27:137-143 | ||
| Venous ulcer (controls) | Twenty subjects with venous ulcers (CEAP C4-6) as described in: J Vasc Surg. 2004 Dec;40(6):1248-52 |
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| Measure | Description | Time Frame |
|---|---|---|
| Martorell HYTILU and calciphylaxis show both decreased tissue protection mechanisms against tissue calcification | Comparison of the calcification-protective factors GLA-1(serum protein alpha2-Heremans-Schmid glycoprotein/fetuin A), Osteoprotegerin, Fibroblast Growth Factor 23, and Alphafetoin in:
| 36 months |
| Measure | Description | Time Frame |
|---|---|---|
| Martorell hypertensive ischemic leg ulcer and calciphylaxis are both characterized by non-infectious inflammation | Comparison of C-reactive protein, procalcitonin and white blood cell count in:
| 36 months |
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Inclusion Criteria:
Exclusion Criteria:
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n=20: Having Martorell hypertensive ischemic leg ulcer (as defined above) or n=10: Having Calciphylaxis (calcific uremic arteriolopathy (as defined above) or n=20: Having a venous ulcer (as defined above) (controls)
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| Name | Affiliation | Role |
|---|---|---|
| Jürg Hafner, Professor | Department of Dermatology, University Hospital of Zurich, Switzerland | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Dermatology, University Hospital of Zurich | Zurich | Canton of Zurich | CH-8091 | Switzerland |
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| ID | Term |
|---|---|
| D002115 | Calciphylaxis |
| D006973 | Hypertension |
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D002114 | Calcinosis |
| D002128 | Calcium Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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Blood serum (2 tubes); blood plasma in citrate (2 tubes); blood plasma in heparin (2 tubes) Diseased skin tissue in formalin for paraffin embedded H-E histology; Diseased skin tissue snap frozen Diseased skin tissue in "RNA later" tube (1 tube)
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D044882 | Glucose Metabolism Disorders |
| D004700 | Endocrine System Diseases |