Efficacy Assessment of Systematic Treatment With Folinic Acid and Thyroid Hormone on Psychomotor Development of Down Syndrome Young Children

Efficacy Assessment of Systematic Treatment With Folinic Acid and Thyroid Hormone on Psychomotor Development of Down Syndrome Young Children

Evaluation of the following in very young children with Down syndrome:

• the efficacy of systematic treatment with L-thyroxine at controlled doses (clinically and by ultrasensitive thyreostimulating hormone (TSH) assay),
• the efficacy of systematic folinic acid treatment at a dose of 1 mg/kg/o.i.d,
• any interaction between these two treatments.

Inclusion Criteria:

• patient with a karyotype demonstrating homogeneous, free or Robertsonian translocation trisomy 21
• patient having undergone a cardiac ultrasound not demonstrating any severe heart disease
• patient aged 6 to 18 months at inclusion

Exclusion Criteria:

• congenital hypothyroidism
• hypothyroidism demonstrated by laboratory tests (TSH > 7mUI/l)
• presenting or having presented hyperthyroidism
• presenting or having presented leukaemia
• presenting or having presented West syndrome or any other form of epilepsy or unstable neurological disease
• presenting or having presented signs of central nervous system distress: stroke, postoperative hypoxia, meningitis)
• presenting severe heart disease on cardiac ultrasound, with haemodynamic effects
• presenting non-controlled cardiac arrhythmia
• Apgar < 7 to 5 min at birth
• Gestational age < 231 days (33 gestation weeks)