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| ID | Type | Description | Link |
|---|---|---|---|
| COG-AREN12B6 | Other Identifier | Children's Oncology Group | |
| CDR0000730596 | Other Identifier | Clinical Trials.gov | |
| AREN12B6 | Other Identifier | Children's Oncology Group | |
| NCI-2012-00726 | Registry Identifier | CTRP (Clinical Trial Reporting Program) |
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| Name | Class |
|---|---|
| National Cancer Institute (NCI) | NIH |
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RATIONALE: Studying samples of blood and tissue from newborns and from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research trial studies cord blood and placenta tissue from newborns, and tumor tissue samples from patients with Wilms tumor.
OBJECTIVES:
OUTLINE: Archived tumor tissue, cord blood, and placenta samples are analyzed for DNA methylation, single nucleotide polymorphism, and gene expression by polymerase chain reaction (PCR), pyrosequencing, and quantitative real-time PCR. Information regarding gender and age of the samples are also collected, if possible.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| DNA methylation analysis | Genetic | |||
| RNA analysis | Genetic | |||
| allele-specific oligonucleotide real-time quantitative polymerase chain reaction | Genetic | |||
| gene expression analysis | Genetic | |||
| nucleic acid sequencing | Genetic | |||
| polymorphism analysis | Genetic | |||
| laboratory biomarker analysis | Other |
| Measure | Description | Time Frame |
|---|---|---|
| Frequency of loss of imprinting at birth | ||
| Association between methylation levels and gene expression |
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DISEASE CHARACTERISTICS:
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
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Patients registered on Children's Oncology Group Wilms tumor protocols
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| Name | Affiliation | Role |
|---|---|---|
| Karin Michels, MD, PhD | Dana-Farber/Brigham and Women's Cancer Center | Principal Investigator |
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blood and tissue
| ID | Term |
|---|---|
| D007680 | Kidney Neoplasms |
| D009396 | Wilms Tumor |
| ID | Term |
|---|---|
| D014571 | Urologic Neoplasms |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052801 | Male Urogenital Diseases |
| D018193 | Neoplasms, Complex and Mixed |
| D009370 | Neoplasms by Histologic Type |
| D009386 | Neoplastic Syndromes, Hereditary |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
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| ID | Term |
|---|---|
| D019175 | DNA Methylation |
| D020869 | Gene Expression Profiling |
| D001483 | Base Sequence |
| D054458 | Amplified Fragment Length Polymorphism Analysis |
| ID | Term |
|---|---|
| D008745 | Methylation |
| D000478 | Alkylation |
| D001669 | Biochemical Phenomena |
| D055598 | Chemical Phenomena |
| D008660 | Metabolism |
| D055614 | Genetic Phenomena |
| D005821 | Genetic Techniques |
| D008919 | Investigative Techniques |
| D015394 | Molecular Structure |
| D040342 | Genetic Structures |
| D016172 | DNA Fingerprinting |
| D016133 | Polymerase Chain Reaction |
| D021141 | Nucleic Acid Amplification Techniques |
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