Oral Trehalose Therapy to Reverse Arterial Aging in Middle-Aged and Older Adults

Oral Trehalose Therapy to Reverse Arterial Aging in Middle-Aged and Older Adults

The proposed study will assess the ability of a naturally occurring sugar to improve the function of arteries with age. Overall, the proposed research project has the long-term potential to influence clinical practice guidelines by establishing a novel, easy to deliver, cost-effective therapy for treating age-associated arterial dysfunction and reducing the risk of cardiovascular disease with age.

Inclusion Criteria:

• women must be postmenopausal
• body mass index (BMI) <40 kg/m2
• weight stable in the prior 3 months
• absence of clinical disease as determined by medical history, physical examination, blood and urine chemistries, ankle-brachial index, and a graded exercise stress test with monitoring of blood pressure and 12-lead ECG