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The proposed study will assess the ability of a naturally occurring sugar to improve the function of arteries with age. Overall, the proposed research project has the long-term potential to influence clinical practice guidelines by establishing a novel, easy to deliver, cost-effective therapy for treating age-associated arterial dysfunction and reducing the risk of cardiovascular disease with age.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Maltose | Placebo Comparator |
| |
| High-dose trehalose | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo | Drug | 100g maltose 1/day |
| |
| High-dose trehalose |
| Measure | Description | Time Frame |
|---|---|---|
| Arterial Stiffness | Arterial pulse wave velocity | 12 weeks |
| nitric-oxide mediated endothelium-dependent dilation | flow-mediated dilation and forearm blood flow responses to acetylcholine in the presence and absence of N'-monomethyl-L-arginine | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Systemic oxidative stress and inflammation | circulating markers of oxidative stress and inflammation | 12 weeks |
| Endothelial cell oxidative stress and inflammation | inflammatory and oxidative stress markers in biopsied vascular and arterial endothelial cells |
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Inclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Rachelle E Kaplon, MS | University of Colorado, Denver | Study Director |
| Douglas R Seals, PhD | University of Colorado, Denver | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Colorado, Boulder Clinical Translational Research Center | Boulder | Colorado | 80309 | United States |
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| Label | URL |
|---|---|
| Description of our Research and Laboratory | View source |
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| ID | Term |
|---|---|
| D014199 | Trehalose |
| ID | Term |
|---|---|
| D005936 | Glucans |
| D011134 | Polysaccharides |
| D002241 | Carbohydrates |
| D004187 | Disaccharides |
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| Drug |
100g 1/day |
|
| 12 weeks |
| Insulin sensitivity | intravenous glucose tolerance test | 12 weeks |
| Endothelial cell autophagic flux | 12 weeks |
| D009844 |
| Oligosaccharides |
| D000073893 | Sugars |