A Multicenter, Open-Label, Single-Arm Study of Pertuzumab in Combination With Trastuzumab and a Taxane in First Line Treatment of Patients With HER2-Positive Advanced (Metastatic or Locally Recurrent) Breast Cancer
A Multicenter, Open-Label, Single-Arm Study of Pertuzumab in Combination With Trastuzumab and a Taxane in First Line Treatment of Patients With HER2-Positive Advanced (Metastatic or Locally Recurrent) Breast Cancer
This multicenter, open-label, single-arm, Phase IIIb study will evaluate the safety and tolerability of pertuzumab in combination with trastuzumab (Herceptin) and a taxane (docetaxel, paclitaxel or nab-paclitaxel) in first-line treatment in participants with metastatic or locally recurrent HER2-positive breast cancer. Participants will receive pertuzumab intravenously (IV) and trastuzumab (Herceptin) IV plus a taxane in cycles of 3 weeks each until predefined study end, unacceptable toxicity, withdrawal of consent, disease progression, or death, whichever occurs first.
Inclusion Criteria:
Exclusion Criteria:
Vienna, 1090, Austria
Vienna, 1090, Austria
Montreal, Quebec H3T 1E2, Canada
Xi'an, 710032, China
LeMans, 72000, France
Hanover, 30177, Germany
Heidelberg, 69120, Germany
Homburg/Saar, 66424, Germany
Lübeck, 23538, Germany
München, 81675, Germany
Crete, 711 10, Greece
Miskolc, 3501, Hungary
Szeged, 6720, Hungary
Piacenza, Emilia-Romagna 29100, Italy
Udine, Friuli Venezia Giulia 33100, Italy
Legnago, Lombardy 37045, Italy
Pavia, Lombardy 27100, Italy
D.F., 04980, Mexico
D.F., 14050, Mexico
Queretaro, Queretaro, 76090, Mexico
Lima, Lima 41, Peru
Lima, Lima11, Peru
Lodz, 93-513, Poland
Otwock, 05-400, Poland
Santiago de Compostela, LA Coruña 15706, Spain
Las Palmas de Gran Canaria, LAS Palmas 35016, Spain
Las Palmas de Gran Canaria, LAS Palmas 35020, Spain
Navarra, Navarre 31008, Spain
Santa Cruz de Tenerife, Tenerife 38010, Spain
Madrid, 28050, Spain
Adana, 01250, Turkey (Türkiye)
Bornova, İ̇zmi̇r, 35100, Turkey (Türkiye)
Edirne, 22770, Turkey (Türkiye)
Sihhiye/Ankara, 06230, Turkey (Türkiye)
Dnipropetrovsk, 49102, Ukraine
New Castle Upon Tyne, NE7 7DN, United Kingdom
Somerset, TA1 5DA, United Kingdom
Montevideo, 11400, Uruguay