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| Name | Class |
|---|---|
| Lundbeck Foundation | OTHER |
| Aarhus University Hospital | OTHER |
| Vejle Hospital | OTHER |
| Esbjerg Hospital - University Hospital of Southern Denmark |
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The purpose of the present study is to conduct a thorough and relevant physiology study of carriers and non-carriers of the gene variant X in order to determine the effect of the genetic variant on various metabolic parameters.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Carriers | Experimental |
| |
| Non-carriers | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| first phase insulin secretion (FPIR), Hyperinsulinemic euglycemic clamp (HEC), glucose tracer, and palmitate tracer | Other | FPIR: intravenous infusion of 20 % glucose 0.3 mg/kg in 2 minutes followed by blood sampling at times 0, 2, 4, 6, 8, and 10. Duration 10 minutes. HEC: intravenous infusion of actrapid 1mU/kg/minute, simultaneous infusion of 20 % glucose at variable rate to reach plasma blood glucose level of 5 mmol/L. Duration 120 minutes Glucose tracer: bolus of 3H3glucose (12µCi) followed by infusion of 3H3glucose (0,12 µCi/min). Duration 120 minutes. Palmitate tracer:[9,10-3H]-palmitate 0,3 µCi/min. Duration 60 minutes. |
| Measure | Description | Time Frame |
|---|---|---|
| insulin secretion | Estimation of first phase insulin secretion | 10 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Insulin resistance | Estimation of insulin resistance using hyperinsulinemic euglycemic clamp and glucose and lipid tracers | 240 minutes |
| body composition | Evaluation of body composition using Dxa scan and MRI scan |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Niels Møller, Professor | University of Aarhus | Principal Investigator |
| Oluf B Pedersen, Professor | Steno Diabetes Center Copenhagen | Principal Investigator |
| Torben Hansen, Professor | Steno Diabetes Center Copenhagen | Principal Investigator |
| Jørgen Rungby, Professor | University of Aarhus | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medicinsk forskningslaboratorium, Aarhus Universitet | Aarhus | 8000 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26336608 | Derived | Stoy J, Kampmann U, Mengel A, Magnusson NE, Jessen N, Grarup N, Rungby J, Stodkilde-Jorgensen H, Brandslund I, Christensen C, Hansen T, Pedersen O, Moller N. Reduced CD300LG mRNA tissue expression, increased intramyocellular lipid content and impaired glucose metabolism in healthy male carriers of Arg82Cys in CD300LG: a novel genometabolic cross-link between CD300LG and common metabolic phenotypes. BMJ Open Diabetes Res Care. 2015 Aug 26;3(1):e000095. doi: 10.1136/bmjdrc-2015-000095. eCollection 2015. | |
| 25314291 |
| Label | URL |
|---|---|
| Project home page | View source |
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| OTHER |
| Steno Diabetes Center Copenhagen | OTHER |
| University of Copenhagen | OTHER |
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|
| 60 minutes |
| atherosclerosis | Evaluation of presence and severity of atherosclerosis using ultrasound scan of the common carotide artery | 30 minutes |
| biochemical blood profiling | Various tests run on blood samples | at baseline |
| Insulin resistance | Biopsi from muscle and adipose tissue performed at baseline and during clamp study. | 60 minutes |
| Blood pressure | Measurement of blood pressure every 20. minutes/24 hours | 24 hours |
| Indirect calorimetry | Estimation of resting energy expenditure and respiratory quotient | 60 minutes |
| Derived |
| Stoy J, Grarup N, Horlyck A, Ibsen L, Rungby J, Poulsen PL, Brandslund I, Christensen C, Hansen T, Pedersen O, Moller N, Kampmann U. Blood pressure levels in male carriers of Arg82Cys in CD300LG. PLoS One. 2014 Oct 14;9(10):e109646. doi: 10.1371/journal.pone.0109646. eCollection 2014. |
| ID | Term |
|---|---|
| D006949 | Hyperlipidemias |
| D003920 | Diabetes Mellitus |
| D024821 | Metabolic Syndrome |
| D006973 | Hypertension |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050171 | Dyslipidemias |
| D052439 | Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D044882 | Glucose Metabolism Disorders |
| D004700 | Endocrine System Diseases |
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| C120529 | NDC80 protein, human |
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