Treatment of Non-alcoholic Steatohepatitis (NASH) Patients With Vitamin D

Test the efficacy of vitamin D to improve non-alcoholic steatohepatitis with regard to biochemical and histological parameters.

• Trial with medicinal product

Inclusion criteria:

• Patients with 25-OH vitamin D insufficiency
• Elevated alanine aminotransferase level
• Diagnosis of definite or possible steatohepatitis (NASH)

Exclusion criteria:

• Cirrhosis, present liver disease other than NASH
• Serious diseases limiting life expectancy,
• Breast-feeding or pregnant women
• Unhealthy alcohol consumption
• Drug abuse or substitution therapy
• Use of vitamin preparations within the previous 6 months and during the study
• Weight loss >5% within 12 months before study entry
• Newly diagnosed Diabetes mellitus requiring medical treatment within 12 months before study entry
• Use of anti-obesity drugs
• Previous or current hypercalcemia
• Chronic renal disease