Various maneuvers are commonly used to achieve the ideal operative field necessary for successful endoscopic sinus surgery (ESS). Dexmedetomidine, a potent alpha2 adrenoceptor agonist which dose-dependently reduces arterial blood pressure and heart rate, decreases the hemodynamic and catecholamine response. And dexmedetomidine has an effect of peripheral vasoconstriction thus it is thus theologically appropriate for reducing bleeding during intranasal operation.

The aim of this study is to compare the effect of dexmedetomidine, an alpha2-adrenoreceptor agonist, on intraoperative bleeding, propofol requirement and postoperative profiles to remifentanil , an ultrashort-acting opioid.

Inclusion Criteria:

• ASA Ⅰ-Ⅱ
• Aged between 20 and 70 year
• General anesthesia for endoscopic sinus surgery

Exclusion Criteria:

• Body mass index >30
• Congestive heart failure, Sinus Bradycardia(<50 BPM), Uncontrolled hypertension,
• Coagulopathy
• Drug addiction
• Pregnancy
• Allergic fungal infection