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| Name | Class |
|---|---|
| Fellesjuice AS | UNKNOWN |
| Nofima | OTHER |
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The purpose of this study is to investigate the effects of berry juices containing different levels of polyphenols on blood pressure and other cardiovascular risk factors.
The study is a 12 week double blinded randomized controlled intervention trial. The subjects will be divided in three groups where one receives a placebo juice while the two other will consume 0.5 liter of juice containing different levels of polyphenols. Blood pressure will be monitored and blood samples will be taken.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Placebo Comparator | 12 weeks intake of 0.5 liter/day placebo juice containing sugar, aromas and salt corresponding to the berry juices in the other groups. Blood pressure will be taken at time point 0,6 and 12 weeks. Blood and urine samples will be collected and weight and bioelectric impedance will be monitored at time point 0 and 12 weeks. |
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| Mana-juice | Active Comparator | 12 weeks intake of 0.5 liter/day of a commercially available berry juice (Mana blue) rich in polyphenols (grape, cherries, bilberries and aronia). Blood pressure will be taken at time point 0,6 and 12 weeks. Blood and urine samples will be collected and weight and bioelectric impedance will be monitored at time point 0 and 12 weeks. |
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| Optijuice | Active Comparator | 12 weeks intake of 0.5 liter/day of berry juice rich in polyphenols (grape, cherries, blueberry and aronia) and added extract from press cake of black currant. Blood pressure will be taken at time point 0,6 and 12 weeks. Blood and urine samples will be collected and weight and bioelectric impedance will be monitored at time point 0 and 12 weeks. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo | Dietary Supplement | 500 ml/day Per 100g 6.25 g sucrose 6.25 g maltodextrin 1.3 g citric acid E330 (pH 3.0) 2.5 g Carmine solution E120 (4% carmine colouring agent) 0.025 g blueberry aroma Potassium sorbate E202 water |
| Measure | Description | Time Frame |
|---|---|---|
| Systolic and diastolic blood pressure | Change in blood pressure from baseline to 6 weeks and 12 weeks | Screening, baseline, 6 and 12 weeks |
| Platelet aggregation | Change in platelet aggregation from intervention start till end analyzed by PFA100. | Baseline and 12 weeks |
| Cardiovascular disease risk factors | The effect of polyphenole-rich diet on cardiovascular disease risk factors in blood samples will be analyzed. | Baseline and 12 weeks |
| Diabetes related parameters in blood and urine | The effect of different doses and types of polyphenoles on diabetes related biomarkers in blood and urine will be analyzed. | Baseline and 12 weeks |
| Blood cell expression of stress-response and CVD related genes | Effect of polyphenole-rich diet on blood cell expression of stress-response and cardiovascular disease related genes by low density array and/or whole genome expression (microarray). | Baseline and 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Polymorphisms in cardiovascular disease related genes | Single nucleotide polymorphisms will be analyzed and eventually grouped and compared with the mentioned outcome measures to reveal individual mechanisms of the hypothetized effects of the intervention. | Baseline |
| Whole genome transcription profiles and methylation patterns |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Rune Blomhoff, PhD | University of Oslo | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Oslo | Oslo | Norway |
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| ID | Term |
|---|---|
| D058246 | Prehypertension |
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| Mana-juice | Dietary Supplement | 500 ml/day of a grape,cherry, bilberry,aronia juice 13g carbohydrates/100g 150mg K/100g |
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| Optijuice | Dietary Supplement | 500 ml/day of a Grape,cherry, bilberry,aronia, black current juice 13g carbohydrates/100g 150mg K/100g |
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Effects of polyphenoles on transcription profiles and methylation pattern will be analyzed. |
| Baseline and 12 weeks |