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This study follows the results of the COMPALICLAMP study (NCT00951392) where the investigators showed a differential expression of sirtuins protein isoforms, Sirt6, in muscle depending on the quality of aging. The investigators seek to confirm this difference in expression level of circulating leukocytes on a larger sample.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Single Arm | Other |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood sample | Biological | It is a single cross sectional study. All outcome measures will be taken during the investigation with physical examination, questionnaire and a blood sample |
| Measure | Description | Time Frame |
|---|---|---|
| Sirt6 expression in circulating leukocytes based on the aging quality | analysis by quantitative RT-PCR method | participants will be followed for the duration of the visit, an expected average of 1 day |
| Measure | Description | Time Frame |
|---|---|---|
| hand and forearm muscular strength measurement | Hand Grip strength test | participants will be followed for the duration of the visit, an expected average of 1 day |
| Physical examination and anthropometric measurement |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Martine LAVILLE, Pr | Centre de recherche en nutrition humaine Rhone-Alpes | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre de recherche en nutrition humaine Rhone-Alpes | Pierre-Bénite | 69310 | France | |||
| Centre de Recherche en Nutrition Humaine |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29657112 | Result | Betry C, Meugnier E, Pflieger M, Grenet G, Hercberg S, Galan P, Kesse-Guyot E, Vidal H, Laville M. High expression of CPT1b in skeletal muscle in metabolically healthy older subjects. Diabetes Metab. 2019 Apr;45(2):152-159. doi: 10.1016/j.diabet.2018.01.018. Epub 2018 Feb 12. |
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| ID | Term |
|---|---|
| D008659 | Metabolic Diseases |
| ID | Term |
|---|---|
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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Measurement of the weight, height, waist, hips, blood pressure, pulse.
| participants will be followed for the duration of the visit, an expected average of 1 day |
| Cognitive assessment | MMSE (Mini Mental State Examination), Five-word test, clock drawing | participants will be followed for the duration of the visit, an expected average of 1 day |
| Physical Activity questionnaire | MAQ (Modifiable Activity Questionnaire) | participants will be followed for the duration of the visit, an expected average of 1 day |
| Pierre-Bénite |
| 69310 |
| France |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |