The aims of the study are to investigate the physiological responses associated with deqi during stimulation of the LI11 and LI4 acupuncture points and the correlation between the intensity of the deqi sensation to such responses.

Inclusion Criteria:

1. Normal healthy subjects who were naïve to acupuncture
2. Able to read Chinese and no communication barrier

Exclusion Criteria:

1. Subjects with medical disorders, including neurological and psychologic disorder
2. Use of medications that may affect the cardiovascular system within one week
3. Subjects with painful or uncomfortable sensations of upper and lower limbs