| Primary | 24hr Urinary Sodium | Amount of sodium excreted in urine over 24hr ending on Day 7 | 24hr urine samples ending on Day 7 were collected for 13 healthy controls and 14 patients with POTS | Posted | | Median | Inter-Quartile Range | milliequivalents | | Day 6 am - Day 7 am for each dietary sodium level | | | | ID | Title | Description |
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| OG000 | Healthy Participants Who Consumed Low Sodium Diet as Intervention A or Intervention B | Healthy controls were randomly assigned the order of dietary sodium levels. All procedures were performed at both levels. Results below were after the low sodium diet. Urine was collected daily for a 24hr period ending at approximately 8am. These results are for the final urine collection which ended on Day 7. | | OG001 | Healthy Participants Who Consumed High Sodium Diet as Intervention A or Intervention B | Healthy controls were randomly assigned the order of dietary sodium levels. All procedures were performed at both levels. Results below were after the high sodium diet. Urine was collected daily for a 24hr period ending at approximately 8am. These results are for the final urine collection which ended on Day 7. | | OG002 | Postural Tachycardia Syndrome (POTS) Participants Who Consumed Low Sodium Diet. | Patients with POTS were randomly assigned the order of dietary sodium levels. All procedures were performed at both levels. Results below were after the low sodium diet. Urine was collected daily for a 24hr period ending at approximately 8am. These results are for the final urine collection which ended on Day 7. | | OG003 | Postural Tachycardia Syndrome (POTS) Participants Who Consumed High Sodium Diet | Patients with POTS were randomly assigned the order of dietary sodium levels. All procedures were performed at both levels. Results below were after the high sodium diet. Urine was collected daily for a 24hr period ending at approximately 8am. These results are for the final urine collection which ended on Day 7. |
| | Units | Counts |
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| Participants | - OG00013
- OG00113
- OG00214
- OG003
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| | Title | Denominators | Categories |
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| | | Title | Measurements |
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| - OG00016.8(12 to 26.6)
- OG001280(232 to 306)
- OG00214.7(10.8 to 22.6)
- OG003
|
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| |
| Primary | 24hr Urinary Dopamine | Amount of dopamine excreted in urine over 24 hours ending on Day 7 | 24hr urine samples ending on Day 7 were collected for 13 healthy controls and 14 patients with POTS | Posted | | Median | Inter-Quartile Range | micrograms | | Between Day 6 am - Day 7 am of each dietary sodium level | | | | ID | Title | Description |
|---|
| OG000 | Healthy Participants Who Consumed Low Sodium Diet as Intervention A or Intervention B | Healthy controls were randomly assigned the order of dietary sodium levels. All procedures were performed at both levels. Results below were after the low sodium diet. Urine was collected daily for a 24hr period ending at approximately 8am. These results are for the final urine collection which ended on Day 7. | | OG001 | Healthy Participants Who Consumed High Sodium Diet as Intervention A or Intervention B | Healthy controls were randomly assigned the order of dietary sodium levels. All procedures were performed at both levels. Results below were after the high sodium diet. Urine was collected daily for a 24hr period ending at approximately 8am. These results are for the final urine collection which ended on Day 7. | | OG002 | Postural Tachycardia Syndrome (POTS) Participants Who Consumed Low Sodium Diet. | |
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| Secondary | Plasma Volume | Plasma volume (PV) was determined by the indicator tracer-dilution technique, using the DAXOR Blood Volume Analyzer (BVA)-100 system (DAXOR Corporation), on Day 7 of the low sodium and high sodium dietary interventions. | No data analysis for 1 healthy control who had poor venous access on Day 7 of the high sodium diet. | Posted | | Median | Inter-Quartile Range | mL | | after 7 days of each dietary sodium level | | | | ID | Title | Description |
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| OG000 | Healthy Participants Who Consumed Low Sodium Diet as Intervention A or Intervention B | Healthy controls were randomly assigned the order of dietary sodium levels. All procedures were performed at both levels. Results below were after the low sodium diet. Plasma Volume: Using injection of iodinated I-131 tagged human serum albumin, blood samples were drawn before and 30 minutes after injection on Day 7 of the diet. | | OG001 | Healthy Participants Who Consumed High Sodium Diet as Intervention A or Intervention B | Healthy controls were randomly assigned the order of dietary sodium levels. All procedures were performed at both levels. Results below were after the high sodium diet. Plasma Volume: Using injection of iodinated I-131 tagged human serum albumin, blood samples were drawn before and 30 minutes after injection on Day 7 of the diet. | | OG002 | Postural Tachycardia Syndrome (POTS) Participants Who Consumed Low Sodium Diet. |
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| Secondary | Magnitude of Orthostatic Tachycardia | Whether the magnitude of the heart rate increase that occurs in patients with POTS when moving from a supine to an upright position is attenuated by a High Sodium diet relative to a Low Sodium diet. Heart rate was assessed after overnight rest and fasting after midnight, following at least 60 minutes of lying quietly. Heart rate was then measured at intervals after subjects had been standing for up to 30 minutes (as tolerated). Differences between supine and standing values are presented for 5 minutes standing (or maximal stand if <5 minutes) since several patients were unable to stand for 10 minutes. Data in POTS patients were compared to that of Healthy Controls. | Data is not included for 1 patient with POTS on a Low Sodium diet since that patient was unable to stand for even 1 minute. | Posted | | Median | Inter-Quartile Range | beats per minute | | Supine and upright heart rate were measured after 6 days of each dietary sodium level | | | | ID | Title | Description |
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| OG000 | Healthy Participants Who Consumed Low Sodium Diet as Intervention A or Intervention B | Healthy controls were randomly assigned the order of dietary sodium levels. All procedures were performed at both levels. Results below were after the low sodium diet. Supine and upright heart rate were measured on the 6th day of low sodium diet. | | OG001 | Healthy Participants Who Consumed High Sodium Diet as Intervention A or Intervention B | Healthy controls were randomly assigned the order of dietary sodium levels. All procedures were performed at both levels. Results below were after the high sodium diet. Supine and upright heart rate were measured on the 6th day of high sodium diet. |
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| Secondary | Upright Symptom Score | Whether upright symptoms were improved in patients with POTS on a High Sodium diet relative to a Low Sodium diet. Patients were asked to report their standing symptom burden at the end of the Stand portion of the posture study, using the Vanderbilt Orthostatic Symptoms Scale (VOSS). They rated the severity of nine symptoms (palpitations, lightheadedness, mental confusion, blurred vision, shortness of breath, tremulousness, chest discomfort, headache, and nausea) on a scale ranging from a minimum of 0 (reflecting an absence of symptoms) to a maximum score of 10. The sum of the individual symptom scores was used to calculate orthostatic symptom burden for each participant. The lowest possible total score was 0, if a participant scored all 9 questions as 0, and the highest possible score was 90, if a participant scored all 9 questions as 10. Higher scores indicated worse symptoms. | Upright symptom scores were inadvertently not obtained for the following number of participants: Healthy Participants on Low Sodium diet: 3 Healthy Participants on High Sodium diet: 2 Patients with POTS on Low Sodium diet: 5 Patients with POTS on High Sodium diet: 6 | Posted | | Median | Inter-Quartile Range | score on a scale | | Upright symptoms were assessed on the 6th day of low or high sodium diet. | | | | ID | Title | Description |
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| OG000 | Healthy Participants Who Consumed Low Sodium Diet as Intervention A or Intervention B | Healthy controls were randomly assigned the order of dietary sodium levels. All procedures were performed at both levels. Results below were after the low sodium diet. Upright symptoms were assessed on the 6th day of low sodium diet. |
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| Secondary | Urinary Sodium Following Change in Dietary Sodium Days 1-2 | Urinary sodium excretion will be measured every 24 hours as the participant adapts from the 150 mEq Na/day diet to the 10 and 300 mEq Na/day diets. | One healthy control neglected to collect urine during this time interval on low sodium diet, and a urine sample for another healthy control on high sodium diet was inadvertently not analyzed for sodium | Posted | | Median | Inter-Quartile Range | milliequivalents | | 24 hour collections ending on Day 2 of each diet phase | | | | ID | Title | Description |
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| OG000 | Healthy Participants Who Consumed Low Sodium Diet as Intervention A or Intervention B | Healthy controls were randomly assigned the order of dietary sodium levels with low sodium or high sodium diet starting after 1 day of 150 mEq sodium/day. All procedures were performed at both levels. Results below were after the low sodium diet. Urine was collected daily for a 24hr period ending at approximately 8am. These results are for the urine collection which ended on Day 2. | | OG001 | Healthy Participants Who Consumed High Sodium Diet as Intervention A or Intervention B | Healthy controls were randomly assigned the order of dietary sodium levels with low sodium or high sodium diet starting after 1 day of 150 mEq sodium/day. . All procedures were performed at both levels. Results below were after the high sodium diet. Urine was collected daily for a 24hr period ending at approximately 8am. These results are for the urine collection which ended on Day 2. |
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| Secondary | Urinary Dopamine Following Change in Dietary Sodium Days1-2 | Urinary dopamine excretion will be measured every 24 hours as the participant adapts from the 150 mEq Na/day diet to the 10 and 300 mEq Na/day diets. | One healthy control neglected to collect urine during this time interval on the low sodium diet | Posted | | Median | Inter-Quartile Range | micrograms | | 24 hour collections ending on Day 2 of each dietary sodium phase | | | | ID | Title | Description |
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| OG000 | Healthy Participants Who Consumed Low Sodium Diet as Intervention A or Intervention B | Healthy controls were randomly assigned the order of dietary sodium levels with low sodium or high sodium diet starting after 1 day of 150 mEq sodium/day. All procedures were performed at both levels. Results below were after the low sodium diet. Urine was collected daily for a 24hr period ending at approximately 8am. These results are for the urine collection which ended on Day 2. | | OG001 | Healthy Participants Who Consumed High Sodium Diet as Intervention A or Intervention B | Healthy controls were randomly assigned the order of dietary sodium levels with low sodium or high sodium diet starting after 1 day of 150 mEq sodium/day. All procedures were performed at both levels. Results below were after the high sodium diet. Urine was collected daily for a 24hr period ending at approximately 8am. These results are for the urine collection which ended on Day 2. |
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| Secondary | Urinary Sodium Following Change in Dietary Sodium Days 2-3 | Urinary sodium excretion will be measured every 24 hours as the participant adapts from the 150 mEq Na/day diet to the 10 and 300 mEq Na/day diets. | 24hr urine samples were collected and analyzed for 13 healthy controls and 14 patients with POTS during both the low sodium and high sodium diet phases | Posted | | Median | Inter-Quartile Range | milliequivalents | | 24 hour collections ending on Day 3 of each diet phase | | | | ID | Title | Description |
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| OG000 | Healthy Participants Who Consumed Low Sodium Diet as Intervention A or Intervention B | Healthy controls were randomly assigned the order of dietary sodium levels with low sodium or high sodium diet starting after 1 day of 150 mEq sodium/day. All procedures were performed at both levels. Results below were after the low sodium diet. Urine was collected daily for a 24hr period ending at approximately 8am.These results are for the urine collection which ended on Day 3. | | OG001 | Healthy Participants Who Consumed High Sodium Diet as Intervention A or Intervention B | Healthy controls were randomly assigned the order of dietary sodium levels with low sodium or high sodium diet starting after 1 day of 150 mEq sodium/day. All procedures were performed at both levels. Results below were after the high sodium diet. Urine was collected daily for a 24hr period ending at approximately 8am.These results are for the urine collection which ended on Day 3. |
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| Secondary | Urinary Sodium Following Change in Dietary Sodium Days 3-4 | Urinary sodium excretion will be measured every 24 hours as the participant adapts from the 150 mEq Na/day diet to the 10 and 300 mEq Na/day diets. | 24hr urine samples were collected and analyzed for 13 healthy controls and 14 patients with POTS during both the low sodium and high sodium diet phases | Posted | | Median | Inter-Quartile Range | milliequivalents | | 24 hour collections ending on Day 4 of each diet phase | | | | ID | Title | Description |
|---|
| OG000 | Healthy Participants Who Consumed Low Sodium Diet as Intervention A or Intervention B | Healthy controls were randomly assigned the order of dietary sodium levels with low sodium or high sodium diet starting after 1 day of 150 mEq sodium/day. All procedures were performed at both levels. Results below were after the low sodium diet. Urine was collected daily for a 24hr period ending at approximately 8am.These results are for the urine collection which ended on Day 4. | | OG001 | Healthy Participants Who Consumed High Sodium Diet as Intervention A or Intervention B | Healthy controls were randomly assigned the order of dietary sodium levels with low sodium or high sodium diet starting after 1 day of 150 mEq sodium/day. All procedures were performed at both levels. Results below were after the high sodium diet. Urine was collected daily for a 24hr period ending at approximately 8am.These results are for the urine collection which ended on Day 4. |
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| Secondary | Urinary Sodium Following Change in Dietary Sodium Days 4-5 | Urinary sodium excretion will be measured every 24 hours as the participant adapts from the 150 mEq Na/day diet to the 10 and 300 mEq Na/day diets | The urine sample for 1 patient with POTS was collected during this time interval during high sodium diet but it was inadvertently not analyzed. | Posted | | Median | Inter-Quartile Range | milliequivalents | | 24 hour collections ending on Day 5 of each diet phase | | | | ID | Title | Description |
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| OG000 | Healthy Participants Who Consumed Low Sodium Diet as Intervention A or Intervention B | Healthy controls were randomly assigned the order of dietary sodium levels with low sodium or high sodium diet starting after 1 day of 150 mEq sodium/day. All procedures were performed at both levels. Results below were after the low sodium diet. Urine was collected daily for a 24hr period ending at approximately 8am.These results are for the urine collection which ended on Day 5. | | OG001 | Healthy Participants Who Consumed High Sodium Diet as Intervention A or Intervention B | Healthy controls were randomly assigned the order of dietary sodium levels with low sodium or high sodium diet starting after 1 day of 150 mEq sodium/day. All procedures were performed at both levels. Results below were after the high sodium diet. Urine was collected daily for a 24hr period ending at approximately 8am.These results are for the urine collection which ended on Day 5. |
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| Secondary | Urinary Sodium Following Change in Dietary Sodium Days 5-6 | Urinary sodium excretion will be measured every 24 hours as the participant adapts from the 150 mEq Na/day diet to the 10 and 300 mEq Na/day diets. | 24hr urine samples were collected and analyzed for 13 healthy controls and 14 patients with POTS during both the low sodium and high sodium diet phases | Posted | | Median | Inter-Quartile Range | milliequivalents | | 24 hour collections ending on Day 6 of each diet phase | | | | ID | Title | Description |
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| OG000 | Healthy Participants Who Consumed Low Sodium Diet as Intervention A or Intervention B | Healthy controls were randomly assigned the order of dietary sodium levels with low sodium or high sodium diet starting after 1 day of 150 mEq sodium/day. All procedures were performed at both levels. Results below were after the low sodium diet. Urine was collected daily for a 24hr period ending at approximately 8am.These results are for the urine collection which ended on Day 6. | | OG001 | Healthy Participants Who Consumed High Sodium Diet as Intervention A or Intervention B | Healthy controls were randomly assigned the order of dietary sodium levels with low sodium or high sodium diet starting after 1 day of 150 mEq sodium/day. All procedures were performed at both levels. Results below were after the high sodium diet. Urine was collected daily for a 24hr period ending at approximately 8am.These results are for the urine collection which ended on Day 6. |
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| Secondary | Urinary Dopamine Following Change in Dietary Sodium Days 2-3 | Urinary dopamine excretion will be measured every 24 hours as the participant adapts from the 150 mEq Na/day diet to the 10 and 300 mEq Na/day diets. | The urine sample for 1 healthy control was collected during this interval of the low sodium diet phase, but the sample was inadvertently sent to the wrong lab for analysis | Posted | | Median | Inter-Quartile Range | micrograms | | 24 hour collections ending on Day 3 of each dietary sodium phase | | | | ID | Title | Description |
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| OG000 | Healthy Participants Who Consumed Low Sodium Diet as Intervention A or Intervention B | Healthy controls were randomly assigned the order of dietary sodium levels with low sodium or high sodium diet starting after 1 day of 150 mEq sodium/day. All procedures were performed at both levels. Results below were after the low sodium diet. Urine was collected daily for a 24hr period ending at approximately 8am. These results are for the urine collection which ended on Day 3. | | OG001 | Healthy Participants Who Consumed High Sodium Diet as Intervention A or Intervention B | Healthy controls were randomly assigned the order of dietary sodium levels with low sodium or high sodium diet starting after 1 day of 150 mEq sodium/day. All procedures were performed at both levels. Results below were after the high sodium diet. Urine was collected daily for a 24hr period ending at approximately 8am. These results are for the urine collection which ended on Day 3. |
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| Secondary | Urinary Dopamine Following Change in Dietary Sodium Days 3-4 | Urinary dopamine excretion will be measured every 24 hours as the participant adapts from the 150 mEq Na/day diet to the 10 and 300 mEq Na/day diets. | The urine sample for 1 healthy control was collected during this interval of the low sodium diet phase, but the sample was inadvertently sent to the wrong lab for analysis | Posted | | Median | Inter-Quartile Range | micrograms | | 24 hour collections ending on Day 4 of each dietary sodium phase | | | | ID | Title | Description |
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| OG000 | Healthy Participants Who Consumed Low Sodium Diet as Intervention A or Intervention B | Healthy controls were randomly assigned the order of dietary sodium levels with low sodium or high sodium diet starting after 1 day of 150 mEq sodium/day. All procedures were performed at both levels. Results below were after the low sodium diet. Urine was collected daily for a 24hr period ending at approximately 8am. These results are for the urine collection which ended on Day 4. | | OG001 | Healthy Participants Who Consumed High Sodium Diet as Intervention A or Intervention B | Healthy controls were randomly assigned the order of dietary sodium levels with low sodium or high sodium diet starting after 1 day of 150 mEq sodium/day. All procedures were performed at both levels. Results below were after the high sodium diet. Urine was collected daily for a 24hr period ending at approximately 8am. These results are for the urine collection which ended on Day 4. |
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| Secondary | Urinary Dopamine Following Change in Dietary Sodium Days 4-5 | Urinary dopamine excretion will be measured every 24 hours as the participant adapts from the 150 mEq Na/day diet to the 10 and 300 mEq Na/day diets. | Urine was collected and analyzed for 13 healthy controls and 14 patients with POTS during this time interval of the low sodium and high sodium diets | Posted | | Median | Inter-Quartile Range | micrograms | | 24 hour collections ending on Day 5 of each dietary sodium phase | | | | ID | Title | Description |
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| OG000 | Healthy Participants Who Consumed Low Sodium Diet as Intervention A or Intervention B | Healthy controls were randomly assigned the order of dietary sodium levels with low sodium or high sodium diet starting after 1 day of 150 mEq sodium/day. All procedures were performed at both levels. Results below were after the low sodium diet. Urine was collected daily for a 24hr period ending at approximately 8am. These results are for the urine collection which ended on Day 5. | | OG001 | Healthy Participants Who Consumed High Sodium Diet as Intervention A or Intervention B | Healthy controls were randomly assigned the order of dietary sodium levels with low sodium or high sodium diet starting after 1 day of 150 mEq sodium/day. All procedures were performed at both levels. Results below were after the high sodium diet. Urine was collected daily for a 24hr period ending at approximately 8am. These results are for the urine collection which ended on Day 5. |
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| Secondary | Urinary Dopamine Following Change in Dietary Sodium Days 5-6 | Urinary dopamine excretion will be measured every 24 hours as the participant adapts from the 150 mEq Na/day diet to the 10 and 300 mEq Na/day diets. | Urine was collected and analyzed for 13 healthy controls and 14 patients with POTS during this time interval of the low sodium and high sodium diets | Posted | | Median | Inter-Quartile Range | micrograms | | 24 hour collections ending on Day 6 of each dietary sodium phase | | | | ID | Title | Description |
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| OG000 | Healthy Participants Who Consumed Low Sodium Diet as Intervention A or Intervention B | Healthy controls were randomly assigned the order of dietary sodium levels with low sodium or high sodium diet starting after 1 day of 150 mEq sodium/day. All procedures were performed at both levels. Results below were after the low sodium diet. Urine was collected daily for a 24hr period ending at approximately 8am. These results are for the urine collection which ended on Day 6. | | OG001 | Healthy Participants Who Consumed High Sodium Diet as Intervention A or Intervention B | Healthy controls were randomly assigned the order of dietary sodium levels with low sodium or high sodium diet starting after 1 day of 150 mEq sodium/day. All procedures were performed at both levels. Results below were after the high sodium diet. Urine was collected daily for a 24hr period ending at approximately 8am. These results are for the urine collection which ended on Day 6. |
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