Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This clinical trial is to investigate whether nonsteroid anti-inflammatory drops have therapeutic effect on moderate to severe dry eye patients.And compare the efficacy of the two nonsteroid anti-inflammatory drops with topical corticosteroids.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| group 1 | Experimental |
| |
| group 2 | Experimental |
| |
| group 3 | Experimental |
| |
| group 4 | Other |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| nonsteroid anti-inflammatory drops | Drug | nonsteroid anti-inflammatory drops plus artificial tear substitute |
|
| Measure | Description | Time Frame |
|---|---|---|
| tear osmolarity | Day 0, Day 14 |
| Measure | Description | Time Frame |
|---|---|---|
| corneal staining | 0 day,7th day and 14th day after treatment | |
| Schirmer test(without anaesthesia) | 0 day,7th day,14th day after treatment | |
| tear film breakup time(TBUT) |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Wei Chen, MD,PhD | Eye Hospital, Wenzhou Medical College, China | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Eye Hospital, Wenzhou Medical College | Wenzhou | Zhejiang | 325027 | China |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| nonsteroid anti-inflammatory drops | Drug | nonsteroid anti-inflammatory drops plus artificial tear substitute |
|
|
| corticosteroids | Drug | corticosteroids plus artificial tear substitute |
|
|
| artificial tear substitute | Drug | artificial tear substitute alone |
|
| 0 day,7th day and 14th day after treatment |
| meibomian gland function | 0 day,7th day and 14th day after treatment |
| ID | Term |
|---|---|
| D000305 | Adrenal Cortex Hormones |
| D005469 | Fluorometholone |
| ID | Term |
|---|---|
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D011244 | Pregnadienediols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |
Not provided
Not provided