Efficacy of Nonsteroidal Anti-inflammatory Drugs in Treatment of Moderate and Severe Dry Eye Disease

Efficacy of Nonsteroidal Anti-inflammatory Drugs in Treatment of Moderate and Severe Dry Eye Disease

This clinical trial is to investigate whether nonsteroid anti-inflammatory drops have therapeutic effect on moderate to severe dry eye patients.And compare the efficacy of the two nonsteroid anti-inflammatory drops with topical corticosteroids.

Inclusion Criteria:

• moderate to severe dry eye syndrome
• tear film breakup time >0 second and ≤5 seconds,or schirmer test(no anaesthesia)≥2mm/5min and ≤5mm/5min
• corneal staining≥3 scores

Exclusion Criteria:

• allergic to any composition of the drugs under experiment
• previous use of anti-inflammatory drugs or immunosuppressive agent
• viral,bacterial or fungal infection of the eye
• eyelid anomaly
• glaucoma or high IOP
• significant meibomian gland dysfunction