Effect of Vitamin D Supplement on Osteoprotegin Expression and Disease Progression in Patients With Chronic Kidney Disease Stage 1 and 2

Vitamin D Supplement in patients with CKD stage 1 and 2 may change osteoprotegin expression so as to produce beneficial effects of cardiovascular、bone metabolism and CKD progression.

Inclusion Criteria:

• Clinical diagnosis of CKD stage 1 and 2
• Age >18 years
• Ability to provide informed consent

Exclusion Criteria:

• On vitamin D in past 4 weeks
• Plans to relocate out of Taixing City in the next one year
• Serum phosphate >5.5 mg/dl in past 3 months
• Serum calcium >10.0 mg/dl in past 3 months
• Cancer
• Transplanted organ
• Rapidly deteriorating kidney function with the expectation for initiation of dialysis in less than 6 months