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Iodine therapy is the best treatment for graves disease.Most patients receive methimozale prior to radio-iodine treatment. This may decrease treatment response to iodine therapy.
Some physicians advice to discontinue methimazole 3 days before radioiodine therapy and others prefer longer off - methimazole period which bothers most patients. This study aimed to evaluate optimum time for methimazole discontinuation in graves disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| group one | Active Comparator | This group will be advised to discontinue methimazole 24-48 hour before iodine therapy |
|
| group two | Active Comparator | methimazole stopped 48-72 hour before radioiodine therapy |
|
| group three | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Methimazole | Drug | Methimazole was stopped 24-48 before radio-iodine therapy |
| |
| Measure | Description | Time Frame |
|---|---|---|
| thyroid function tests over one year after radioiodine therapy | thyroid function test may change over one year . In order to consider the patients as cured ,thyroid function tests should reveal hypothyroidism or euthyroidism . In order to rule out temporary hypothyroidism the tests should be repeated after 6 months of radioiodine therapy. | months 1 , 3 ,6,9,12 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| rasoul zakavi, associate professor | Mashhad University of Medical Sciences | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mashad University of Medical Sciences | Mashhad | Razavi Khorasan Province | 91766 | Iran |
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| ID | Term |
|---|---|
| D006111 | Graves Disease |
| D006980 | Hyperthyroidism |
| ID | Term |
|---|---|
| D005094 | Exophthalmos |
| D009916 | Orbital Diseases |
| D005128 | Eye Diseases |
| D006042 | Goiter |
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| ID | Term |
|---|---|
| D008713 | Methimazole |
| ID | Term |
|---|---|
| D013438 | Sulfhydryl Compounds |
| D013457 | Sulfur Compounds |
| D009930 | Organic Chemicals |
| D007093 | Imidazoles |
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| Methimazole |
| Drug |
methimazole discontinued 49-72 hours before radioiodine treatment |
|
| Methimazole | Drug | methimazole discontinued 73-168 hours before radio-iodine treatment |
|
| D013959 |
| Thyroid Diseases |
| D004700 | Endocrine System Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D001393 |
| Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |