The purpose of this study is to determine what factors influence the visual outcomes of infants with severe retinopathy of prematurity (ROP) and to monitor the outcomes.

Inclusion Criteria:

• Documentation of informed consent and authorization
• Inborn and those admitted within 7 days of birth
• Infant with a diagnosis of stage 2 ROP or higher
• Site ability to plan close ophthalmological follow-up due to significant and persistent ROP
• Parents must agree to report outcomes following each ophthalmological visit and overall outcomes for up to five (5) years of age
• Ability to obtain follow-up data on outcomes if the child is transferred to another facility
• No known major congenital anomalies

Exclusion Criteria:

• ROP stage 1 or less
• Parents unwilling to participate in follow-up
• Major congenital anomalies

Neonates who have a diagnosis of Retinopathy of Prematurity Stage 2 or higher