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The purpose of this study is to evaluate the efficacy of albumin infusion to prevent post tips hepatic encephalopathy'
The outcome is the prevention of post tips hepatic encephalopathy
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| albumin | Active Comparator | cirrhotic patients who underwent tips placement |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Albumin | Drug | albumin 20% 1 g/Kg body weight for the first two days after TIPS followed by 0,5 g/Kg body weight at day 4 and then 0,5 g/Kg body weight once a week for three weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| one or more episodes of hepatic encephalopathy (> grade 2 according to West Heven criteria)after TIPS placement | evaluate the efficacy of albumin infusion to prevent the occurrence of hepatic encephalopathy (> grade 2 according to West Heven criteria)one months after tips placement | one month post tips |
| Measure | Description | Time Frame |
|---|---|---|
| arterial blood pressure >120/80 mmHg and natremia >130 mg/dl in cirrhotic patients one month after TIPS placement | improving the hypovolemia, evaluated by the arterial blood pressure value, and hyponatremia (<130 mg/dl)after albumine infusion for one month after tips placement | one month after tips placement |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| oliviero riggio, professor | University of Roma La Sapienza | Principal Investigator |
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| ID | Term |
|---|---|
| D006501 | Hepatic Encephalopathy |
| D007010 | Hyponatremia |
| D020896 | Hypovolemia |
| D005355 | Fibrosis |
| ID | Term |
|---|---|
| D017093 | Liver Failure |
| D048550 | Hepatic Insufficiency |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
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| ID | Term |
|---|---|
| D000418 | Albumins |
| D000075462 | Serum Albumin, Human |
| ID | Term |
|---|---|
| D011506 | Proteins |
| D000602 | Amino Acids, Peptides, and Proteins |
| D012709 | Serum Albumin |
| D001798 | Blood Proteins |
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|
| D001928 |
| Brain Diseases, Metabolic |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D014883 | Water-Electrolyte Imbalance |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |