This multicenter, randomized, controlled, open-label, parallel-group, 30-day study took place at four centers in China. The primary objective of this study was to assess the efficacy and safety of hyaluronic acid vaginal gel in treating vaginal dryness. In the current study we tested the hypothesis that the efficacy of hyaluronic acid vaginal gel was not inferior to that of estriol cream, with no clinically significant difference between them, in the treatment of vaginal dryness symptoms.

Inclusion Criteria:

• under 70 years old,
• had been naturally or surgically postmenopausal for more than 6 months,
• had symptoms of vaginal dryness due to various causes and had no contraindications to locally applied estrogen

Exclusion Criteria:

• unmarried, pregnant and breast-feeding women,
• patients with vaginal infections such as trichomonas,
• candida and bacterial vaginosis,
• patients with breast cancer, uterine cancer or estrogen hormone dependent tumors,
• genital bleeding of unknown origin,
• patients with acute hepatopathy, embolic disorders,
• severe primary disease of the kidney and hematopoietic system
• recent malignant tumors