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The investigators will evaluate the National Institute of Health Stroke Scale/Score (NIHSS)in patients with stroke, and then give Minocycline 100mg po every 12 hours or placebo for five days, then perform periodic evaluations to determine the status and degree of neurological sequelae developed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Minocicline | Experimental | minocicline 100mg oral twice a day for 5 days |
|
| Placebo | Placebo Comparator | Pills filled with vegetal fiber with similar presentation of the drug. Given one pill oral twice a day for five days |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Minocicline | Drug | Minocicline 100mg oral twice a day for 5 days |
| |
| Measure | Description | Time Frame |
|---|---|---|
| To determine the efficacy of minocycline in reducing neurological sequelae in patients with stroke | The researchers evaluated the neurological condition of paralysis, aphasia,and level of consciousness by NIHSS score for each patient with stroke and proceeded to give minocycline or placebo. Then, the assessment was repeated after five and thirty days post treatment to determine whether their neurological sequelae had diminushed. | one year |
| Measure | Description | Time Frame |
|---|---|---|
| Identify the side effects of the intervention administered during the treatment time and 30 days later. | one year |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Nataly Bedoya, md | Contact | nata0916@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Nataly Bedoya, Internist | Universidad Surcolombiana | Study Director |
| Hernan Vargas, Internist | Universidad Surcolombiana | Principal Investigator |
| Hugo Osorio, Internist |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital hernando Moncaleano Perdomo | Recruiting | Neiva | Huila Department | Colombia |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| D002545 | Brain Ischemia |
| D010243 | Paralysis |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| Placebo |
| Drug |
Pills with vegetable fibers one pill oral twice a day for five days |
|
| Universidad Surcolombiana |
| Principal Investigator |
| Guillermo Gonzalez, Neurologist | Universidad Surcolombiana | Principal Investigator |
| Javier Saldaña, Epidemiology | Universidad Surcolombiana | Principal Investigator |
| Efrain Amaya, Neurologist | Hospital Hernando Moncaleano Perdomo | Principal Investigator |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |