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| ID | Type | Description | Link |
|---|---|---|---|
| AFIA (initial study name) | Other Identifier | Vestre Viken Hospital Trust and Akershus University Hospital |
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| Name | Class |
|---|---|
| University Hospital, Akershus | OTHER |
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Akershus Cardiac Examination (ACE) 1950 Study is a large, observational, prospective, longitudinal, population-based cohort study. The overall aim is to establish an extensive cardio- and cerebrovascular age cohort of elderly subjects for various longitudinal long-term follow-up studies of cardiovascular and cerebrovascular disease.
Design: The Akershus Cardiac Examination (ACE) 1950 Study is a population-based, prospective, cerebro- and cardiovascular age-cohort study of all men and women born in 1950 in Akershus County, Norway.
Time schedule: Study inclusion and baseline examinations took place in the period September 2012 - May 2015.
Current status: 10-year follow-up examinations of all participants are undertaken in 2023-2025, and sub-studies are ongoing.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| No treatment |
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| Measure | Description | Time Frame |
|---|---|---|
| Outcomes related to CVD and CV-associated conditions | Maximum 35 years |
| Measure | Description | Time Frame |
|---|---|---|
| Specific CV endpoints; e.g. acute myocardial infarction, heart failure, atrial fibrillation, etc. | Maximum 35 years | |
| Specific CV-associated conditions, including renal, cerebrovascular, pulmonary, etc. | Maximum 35 years |
| Measure | Description | Time Frame |
|---|---|---|
| Impact of left atrial size and function measurements by echocardiography on stroke risk in an 62-65-year-old cohort | Within 35 years | |
| Relation between cognitive function and sub-clinical CVD in a 62-65-year-old Norwegian population cohort | Maximum 35 years |
Inclusion Criteria:
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Residents of Akershus County, Norway, born in 1950.
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| Name | Affiliation | Role |
|---|---|---|
| Arnljot Tveit, MD, PhD | Vestre Viken Hospital Trust, Department of Medical Research | Study Director |
| Helge Røsjø, MD, PhD | University Hospital, Akershus | Study Director |
| Trygve Berge - member of steering committee, MD | Vestre Viken Hospital Trust, Department of Medical Research | Principal Investigator |
| Kjetil Steine - member of steering committee, MD, PhD | University Hospital, Akershus | Principal Investigator |
| Torbjørn Omland - member of steering committee, MD, PhD | University Hospital, Akershus | Principal Investigator |
| Magnus N Lyngbakken - member of steering committee, MD | University Hospital, Akershus | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Akershus University Hospital | Lørenskog | Akershus | 1478 | Norway | ||
| Vestre Viken HT, Baerum Hospital, Department of Medical Research |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26364744 | Background | Berge T, Vigen T, Pervez MO, Ihle-Hansen H, Lyngbakken MN, Omland T, Smith P, Steine K, Rosjo H, Tveit A; ACE 1950 Study Group. Heart and Brain Interactions--the Akershus Cardiac Examination (ACE) 1950 Study Design. Scand Cardiovasc J. 2015;49(6):308-15. doi: 10.3109/14017431.2015.1086813. Epub 2015 Sep 12. | |
| 29118784 | Result |
| Label | URL |
|---|---|
| Study website | View source |
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| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| D006333 | Heart Failure |
| D060825 | Cognitive Dysfunction |
| D002318 | Cardiovascular Diseases |
| D002561 | Cerebrovascular Disorders |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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Blood samples, including for genetic testing, and urine.
| Specific clinical phenotypes; e.g. myocardial and arterial structure and function, lung function, etc. | Maximum 35 years |
| Sandvika |
| Akershus |
| 3004 |
| Norway |
| Ihle-Hansen H, Vigen T, Berge T, Einvik G, Aarsland D, Ronning OM, Thommessen B, Rosjo H, Tveit A, Ihle-Hansen H. Montreal Cognitive Assessment in a 63- to 65-year-old Norwegian Cohort from the General Population: Data from the Akershus Cardiac Examination 1950 Study. Dement Geriatr Cogn Dis Extra. 2017 Sep 28;7(3):318-327. doi: 10.1159/000480496. eCollection 2017 Sep-Dec. |
| 29095966 | Result | Berge T, Brynildsen J, Larssen HKN, Onarheim S, Jenssen GR, Ihle-Hansen H, Christophersen IE, Myrstad M, Rosjo H, Smith P, Tveit A. Systematic screening for atrial fibrillation in a 65-year-old population with risk factors for stroke: data from the Akershus Cardiac Examination 1950 study. Europace. 2018 Nov 1;20(FI_3):f299-f305. doi: 10.1093/europace/eux293. |
| 30068617 | Result | Berge T, Lyngbakken MN, Ihle-Hansen H, Brynildsen J, Pervez MO, Aagaard EN, Vigen T, Kvisvik B, Christophersen IE, Steine K, Omland T, Smith P, Rosjo H, Tveit A. Prevalence of atrial fibrillation and cardiovascular risk factors in a 63-65 years old general population cohort: the Akershus Cardiac Examination (ACE) 1950 Study. BMJ Open. 2018 Aug 1;8(7):e021704. doi: 10.1136/bmjopen-2018-021704. |
| 29739796 | Result | Ihle-Hansen H, Vigen T, Ihle-Hansen H, Ronning OM, Berge T, Thommessen B, Lyngbakken MN, Orstad EB, Enger S, Nygard S, Rosjo H, Tveit A. Prevalence of Carotid Plaque in a 63- to 65-Year-Old Norwegian Cohort From the General Population: The ACE (Akershus Cardiac Examination) 1950 Study. J Am Heart Assoc. 2018 May 8;7(10):e008562. doi: 10.1161/JAHA.118.008562. |
| 31123865 | Result | Chandra A, Rosjo H, Eide IA, Vigen T, Ihle-Hansen H, Orstad EB, Ronning OM, Lyngbakken MN, Berge T, Schmidt EB, Omland T, Tveit A, Svensson M. Plasma marine n-3 polyunsaturated fatty acids and cardiovascular risk factors: data from the ACE 1950 study. Eur J Nutr. 2020 Jun;59(4):1505-1515. doi: 10.1007/s00394-019-02007-3. Epub 2019 May 23. |
| 31116158 | Result | Vigen T, Ihle-Hansen H, Lyngbakken MN, Berge T, Thommessen B, Ihle-Hansen H, Orstad EB, Enger S, Ariansen I, Rosjo H, Tveit A, Ronning OM. Blood pressure at age 40 predicts carotid atherosclerosis two decades later: data from the Akershus Cardiac Examination 1950 Study. J Hypertens. 2019 Oct;37(10):1982-1990. doi: 10.1097/HJH.0000000000002131. |
| 31306128 | Result | Ihle-Hansen H, Vigen T, Berge T, Hagberg G, Engedal K, Ronning OM, Thommessen B, Lyngbakken MN, Nygard S, Rosjo H, Tveit A, Ihle-Hansen H. Carotid Atherosclerosis and Cognitive Function in a General Population Aged 63-65 Years: Data from the Akershus Cardiac Examination (ACE) 1950 Study. J Alzheimers Dis. 2019;70(4):1041-1049. doi: 10.3233/JAD-190327. |
| 31504360 | Result | Aagaard EN, Kvisvik B, Pervez MO, Lyngbakken MN, Berge T, Enger S, Orstad EB, Smith P, Omland T, Tveit A, Rosjo H, Steine K. Left ventricular mechanical dispersion in a general population: Data from the Akershus Cardiac Examination 1950 study. Eur Heart J Cardiovasc Imaging. 2020 Feb 1;21(2):183-190. doi: 10.1093/ehjci/jez210. |
| 31889363 | Result | Vigen T, Ihle-Hansen H, Lyngbakken MN, Berge T, Thommessen B, Ihle-Hansen H, Orstad EB, Enger S, Rosjo H, Tveit A, Ronning OM. Carotid Atherosclerosis is Associated with Middle Cerebral Artery Pulsatility Index. J Neuroimaging. 2020 Mar;30(2):233-239. doi: 10.1111/jon.12684. Epub 2019 Dec 30. |
| 32031593 | Result | Ronningen PS, Berge T, Solberg MG, Enger S, Nygard S, Pervez MO, Orstad EB, Kvisvik B, Aagaard EN, Rosjo H, Tveit A, Steine K. Sex differences and higher upper normal limits for left atrial end-systolic volume in individuals in their mid-60s: data from the ACE 1950 Study. Eur Heart J Cardiovasc Imaging. 2020 May 1;21(5):501-507. doi: 10.1093/ehjci/jeaa004. |
| 32227098 | Result | Lyngbakken MN, Aagaard EN, Kvisvik B, Berge T, Pervez MO, Brynildsen J, Tveit A, Steine K, Rosjo H, Omland T. Cardiac Troponin I and T Are Associated with Left Ventricular Function and Structure: Data from the Akershus Cardiac Examination 1950 Study. Clin Chem. 2020 Apr 1;66(4):567-578. doi: 10.1093/clinchem/hvaa023. |
| 32341488 | Result | Chandra A, Rosjo H, Svensson M, Vigen T, Ihle-Hansen H, Orstad EB, Ronning OM, Lyngbakken MN, Nygard S, Berge T, Schmidt EB, Omland T, Tveit A, Eide IA. Plasma linoleic acid levels and cardiovascular risk factors: results from the Norwegian ACE 1950 Study. Eur J Clin Nutr. 2020 Dec;74(12):1707-1717. doi: 10.1038/s41430-020-0641-4. Epub 2020 Apr 27. |
| 32423040 | Result | Chandra A, Lyngbakken MN, Eide IA, Rosjo H, Vigen T, Ihle-Hansen H, Orstad EB, Ronning OM, Berge T, Schmidt EB, Tveit A, Omland T, Svensson M. Plasma Trans Fatty Acid Levels, Cardiovascular Risk Factors and Lifestyle: Results from the Akershus Cardiac Examination 1950 Study. Nutrients. 2020 May 14;12(5):1419. doi: 10.3390/nu12051419. |
| 33279958 | Result | Lyngbakken MN, Kvisvik B, Aagaard EN, Berge T, Pervez MO, Brynildsen J, Tveit A, Steine K, Rosjo H, Omland T. B-Type Natriuretic Peptide Is Associated with Indices of Left Ventricular Dysfunction in Healthy Subjects from the General Population: The Akershus Cardiac Examination 1950 Study. Clin Chem. 2021 Jan 8;67(1):204-215. doi: 10.1093/clinchem/hvaa257. |
| 33861986 | Result | Lyngbakken MN, Vigen T, Ihle-Hansen H, Brynildsen J, Berge T, Ronning OM, Tveit A, Rosjo H, Omland T. Cardiac troponin I measured with a very high sensitivity assay predicts subclinical carotid atherosclerosis: The Akershus Cardiac Examination 1950 Study. Clin Biochem. 2021 Jul;93:59-65. doi: 10.1016/j.clinbiochem.2021.04.005. Epub 2021 Apr 20. |
| 33998259 | Result | Myhre PL, Lyngbakken MN, Berge T, Roysland R, Aagaard EN, Pervez O, Kvisvik B, Brynildsen J, Norseth J, Tveit A, Steine K, Omland T, Rosjo H. Diagnostic Thresholds for Pre-Diabetes Mellitus and Diabetes Mellitus and Subclinical Cardiac Disease in the General Population: Data From the ACE 1950 Study. J Am Heart Assoc. 2021 Jun;10(11):e020447. doi: 10.1161/JAHA.120.020447. Epub 2021 May 17. |
| 34400140 | Result | Myhre PL, Heck SL, Skranes JB, Prebensen C, Jonassen CM, Berge T, Mecinaj A, Melles W, Einvik G, Ingul CB, Tveit A, Berdal JE, Rosjo H, Lyngbakken MN, Omland T. Cardiac pathology 6 months after hospitalization for COVID-19 and association with the acute disease severity. Am Heart J. 2021 Dec;242:61-70. doi: 10.1016/j.ahj.2021.08.001. Epub 2021 Aug 13. |
| 35158418 | Result | Caspersen NF, Soyseth V, Lyngbakken MN, Berge T, Ariansen I, Tveit A, Rosjo H, Einvik G. Treatable Traits in Misdiagnosed Chronic Obstructive Pulmonary Disease: Data from the Akershus Cardiac Examination 1950 Study. Chronic Obstr Pulm Dis. 2022 Apr 29;9(2):165-180. doi: 10.15326/jcopdf.2021.0265. |
| 35621203 | Result | Ronningen PS, Berge T, Solberg MG, Enger S, Pervez MO, Orstad EB, Kvisvik B, Aagaard EN, Lyngbakken MN, Ariansen I, Rosjo H, Steine K, Tveit A. Impact of Blood Pressure in the Early 40s on Left Atrial Volumes in the Mid-60s: Data From the ACE 1950 Study. J Am Heart Assoc. 2022 Jun 7;11(11):e023738. doi: 10.1161/JAHA.121.023738. Epub 2022 May 27. |
| 35919126 | Result | Aagaard EN, Lyngbakken MN, Kvisvik B, Berge T, Pervez MO, Ariansen I, Tveit A, Steine K, Rosjo H, Omland T. Associations between cardiovascular risk factors, biomarkers, and left ventricular mechanical dispersion: insights from the ACE 1950 Study. Eur Heart J Open. 2022 Feb 12;2(2):oeac006. doi: 10.1093/ehjopen/oeac006. eCollection 2022 Mar. |
| 36120822 | Result | Lyngbakken MN, Kvisvik B, Berge T, Pervez MO, Aagaard EN, Ariansen I, Omland T, Tveit A, Steine K, Rosjo H. Serial blood pressure measurements, left ventricular remodelling and cardiovascular outcomes. Eur J Clin Invest. 2023 Jan;53(1):e13876. doi: 10.1111/eci.13876. Epub 2022 Sep 24. |
| 36261282 | Result | Lyngbakken MN, Ronningen PS, Solberg MG, Berge T, Brynildsen J, Aagaard EN, Kvisvik B, Rosjo H, Steine K, Tveit A, Omland T. Prediction of incident atrial fibrillation with cardiac biomarkers and left atrial volumes. Heart. 2023 Feb 14;109(5):356-363. doi: 10.1136/heartjnl-2022-321608. |
| 36453656 | Result | Walle-Hansen MM, Berge T, Vigen T, Myrstad M, Hagberg G, Ihle-Hansen H, Sandset EC, Thommessen B, Ariansen IKH, Lyngbakken MN, Rosjo H, Ronning OM, Tveit A, Ihle-Hansen H. Systolic blood pressure at age 40 and cognitive function 25 years later: the Akershus Cardiac Examination (ACE) 1950 Study. J Hypertens. 2023 Jan 1;41(1):132-139. doi: 10.1097/HJH.0000000000003312. Epub 2022 Oct 20. |
| 37609981 | Result | Ihle-Hansen H, Vigen T, Berge T, Walle-Hansen MM, Hagberg G, Ihle-Hansen H, Thommessen B, Ariansen I, Rosjo H, Ronning OM, Tveit A, Lyngbakken M. Carotid Plaque Score for Stroke and Cardiovascular Risk Prediction in a Middle-Aged Cohort From the General Population. J Am Heart Assoc. 2023 Sep 5;12(17):e030739. doi: 10.1161/JAHA.123.030739. Epub 2023 Aug 23. |
| 41840741 | Derived | Ihle-Hansen H, Walle-Hansen MM, Berge T, Ihle-Hansen H, Ronningen PS, Omland T, Rosjo H, Tveit A, Beyer M, Steine K, Lyngbakken MN, Ronning OM, Vigen T, Quinn T, Cameron A, Hagberg G. Burden of atherosclerosis, cardiovascular risk factors and atrial fibrillation in individuals with covert brain infarcts in late midlife: the Akershus Cardiac Examination 1950 Study. BMJ Open. 2026 Mar 13;16(3):e114232. doi: 10.1136/bmjopen-2025-114232. |
| 41068629 | Derived | Walle-Hansen MM, Hagberg G, Myrstad M, Berge T, Vigen T, Ihle-Hansen H, Thommessen B, Ariansen I, Lyngbakken MN, Rosjo H, Ronning OM, Beyer MK, Tveit A, Ihle-Hansen H. Blood pressure at age 40 and key features of cerebral small vessel disease at age 70: data from the ACE 1950 Study. BMC Cardiovasc Disord. 2025 Oct 9;25(1):724. doi: 10.1186/s12872-025-05140-6. |
| 39909014 | Derived | Dypvik R, Fjukstad KK, Lydersen S, Berge T, Tveit A, Rosjo H, Omland T, Einvik G, Lyngbakken MN. Associations Between Growth Differentiation Factor 15 and Anxiety and Depression in the General Population: The Akershus Cardiac Examination 1950 Study. Biopsychosoc Sci Med. 2025 Feb-Mar 01;87(2):153-159. doi: 10.1097/PSY.0000000000001365. |
| 39179252 | Derived | Walle-Hansen MM, Hagberg G, Myrstad M, Berge T, Vigen T, Ihle-Hansen H, Thommessen B, Ariansen I, Lyngbakken MN, Rosjo H, Ronning OM, Tveit A, Ihle-Hansen H. Systolic blood pressure at age 40 and 30-year stroke risk in men and women. Open Heart. 2024 Aug 22;11(2):e002805. doi: 10.1136/openhrt-2024-002805. |
| 39047714 | Derived | Ihle-Hansen H, Einvik G, Hagberg G, Thommessen B, Ronning OM, Vigen T, Lyngbakken MN, Berge T, Rosjo H, Tveit A, Ihle-Hansen H. Sleep Duration and Cognitive Function: The Akershus Cardiac Examination 1950 Study. Dement Geriatr Cogn Disord. 2024;53(6):338-344. doi: 10.1159/000540273. Epub 2024 Jul 24. |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |