The purpose of the study is to evaluate prospectively the outcome of treatment interventions of knee osteochondral lesions Outerbridge grade III and IV.

The main purpose of the study is to prospectively evaluate the outcome of treatment interventions with replacement, repair and regenerative approaches, of osteochondral articular lesions or defects, Outerbridge grade III and IV, in terms of symptomatic and functional recovery 12 months after surgery.

Inclusion criteria:

patients referred to the participating centers for symptomatic treatment of degenerative lesions of the knee, which meet the following inclusion criteria:

• symptomatic osteochondral lesions of grade III or IV (according to classification of Outerbridge;
• Axial deviation with chondral damage, correct or not;
• Consent to the processing of personal data, signed and dated by patient;
• Patients of both sexes and aged between 30 and 60 years;
• Patients willing to participate actively in the rehabilitation program and to attend post-operative follow-up visits.

Exclusion criteria:

• Patients with synovitis;
• BMI> 30;
• Allergy to collagen or calcium phosphate;
• Patients with neoplastic disease;
• Patients with metabolic disorders, thyroid diseases, immune system disorders.

patients referred to the participating centers for the treatment of symptomatic degenerative lesions of the knee, which meet the following inclusion criteria