-Graded and described using National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) v 4. Safety will be defined as < 2 patients experiencing DLTs of the first 6 treated.

-Only patients enrolled in the safety lead-in were evaluable for this outcome measure

• The HVLT is a word learning test measuring episodic visual memory
• The immediate recall memory deterioration test portion consists of 36 words split into 3 sections (animals, gemstones, places of shelter, types of birds, tools, items of clothing, kitchen utensils,weapons, and alcoholic beverages)
• The words were read aloud and the participants was asked to freely recall them immediately. The list was read a second time followed by a second free recall trial. This was followed by a third reading and third free recall.
• The words recalled for each trial were recorded and a total recall score tallied (range: 0-36).
• The higher the score the better the recall

6 participants were not evaluable for this outcome measure

• The HVLT is a word learning test measuring episodic visual memory
• The immediate recall memory deterioration test portion consists of 36 words split into 3 sections (animals, gemstones, places of shelter, types of birds, tools, items of clothing, kitchen utensils,weapons, and alcoholic beverages)
• The words were read aloud and the participants was asked to freely recall them immediately. The list was read a second time followed by a second free recall trial. This was followed by a third reading and third free recall.
• The words recalled for each trial were recorded and a total recall score tallied (range: 0-36).
• The higher the score the better the recall

11 participants were not evaluable for this outcome measure

• The HVLT is a word learning test measuring episodic visual memory
• The immediate recall memory deterioration test portion consists of 36 words split into 3 sections (animals, gemstones, places of shelter, types of birds, tools, items of clothing, kitchen utensils,weapons, and alcoholic beverages)
• The words were read aloud and the participants was asked to freely recall them immediately. The list was read a second time followed by a second free recall trial. This was followed by a third reading and third free recall.
• The words recalled for each trial were recorded and a total recall score tallied (range: 0-36).
• The higher the score the better the recall

13 participants were not evaluable for this outcome measure

• The HVLT is a word learning test measuring episodic visual memory
• The delayed recall memory deterioration test portion consists of 36 words split into 3 sections (animals, gemstones, places of shelter, types of birds, tools, items of clothing, kitchen utensils,weapons, and alcoholic beverages)
• The words were read aloud and the participants was asked to freely recall them 20-25 minutes later.
• The words recalled were recorded and a total recall score tallied (range: 0-36).
• The higher the score the better the recall

-8 participants were not evaluable for this outcome measure

• The HVLT is a word learning test measuring episodic visual memory
• The delayed recall memory deterioration test portion consists of 36 words split into 3 sections (animals, gemstones, places of shelter, types of birds, tools, items of clothing, kitchen utensils,weapons, and alcoholic beverages)
• The words were read aloud and the participants was asked to freely recall them 20-25 minutes later.
• The words recalled were recorded and a total recall score tallied (range: 0-36).
• The higher the score the better the recall

11 participants were not evaluable for this outcome measure

• The HVLT is a word learning test measuring episodic visual memory
• The delayed recall memory deterioration test portion consists of 36 words split into 3 sections (animals, gemstones, places of shelter, types of birds, tools, items of clothing, kitchen utensils,weapons, and alcoholic beverages)
• The words were read aloud and the participants was asked to freely recall them 20-25 minutes later.
• The words recalled were recorded and a total recall score tallied (range: 0-36).
• The higher the score the better the recall

13 participants were not evaluable for this outcome measure

• Assessed by comparing questionnaire test scores to baseline; European Organization for Research and Treatment of Cancer (EORTC) QLQ30 (global health/QOL, cognitive functioning, and fatigue scales)
• 30 total questions with 28 questions having answers ranging from 1-4 with 1=not at all and 4= very much and 2 questions ranging from 0-7 with 1-very poor and 7=excellent
• Raw scores will be transformed to a 100-point scale (0=lowest score, 100=highest score)
• The higher the score the lower the quality of life

5 participants were not analyzed for this outcome measure

Assessed by comparing questionnaire test scores to baseline; BN20 (future uncertainty and communications deficit scales)

• 20 questions with answers ranging from 1-4 with 1=not at all and 4=very much
• Raw scores will be transformed to a 100-point scale (0=lowest score, 100=highest score)
• The higher the score the lower quality of life

5 participants were not evaluable for this outcome measure

-Defined as at least 4 of 6 patients successfully completing pre-treatment and 3 month post-treatment testing

(1) participant is not evaluable as the participant did not start treatment due to pre-treatment MRI showing metastatic disease in spine.

• 10 participants were evaluable for this outcome measure
• Originally the outcome measure time frame was baseline through 12 months but there was insufficient data to statistically analyze the change in hippocampal morphology at 12 months due to the number of participants still alive for the 12 month scan.

1-year rate of brain metastases

7 participants were not evaluable for this outcome measure

Adverse events will be tabulated by type and grade using NCI CTCAE v 4.

-Overall survival is defined as the time between date of on study and date of death due to any cause

7 participants were not evaluable for this outcome measure