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The purpose of the study is to determine the association between acute kidney injury and serum levels symmetrical and asymmetrical dimethylarginine (SDMA/ADMA) and their assumptive influence on mortality, renal function and on arterial stiffness.
Acute kidney injury (AKI) is a frequent complication with severe implications deteriorating overall prognosis. Nitric oxide (NO)-signal transduction plays an important role in mediating renal damage. NO is produced by NO-synthase (NOS) with L-arginine as its substrate. Endogenous L-Arginine derivatives, asymmetric and symmetric dimethylarginines (ADMA/SDMA), inhibit NO-production directly (AMDA) by blocking NOS activity or indirectly (SDMA) by blocking cellular L-Arginine uptake.
It is well known that SDMA and ADMA are markers of renal function (SDMA) and cardiovascular risk (ADMA/SDMA) in patients with chronic kidney disease (CKD). Moreover, ADMA and SDMA possibly even trigger cardiovascular risk in patients with CKD. However, there is only little information about the regulation and the influence of ADMA/SDMA in acute kidney injury.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| acute kidney injury | Patients with acute kidney injury according to the definition of AKIN (Acute Kidney Injury Network) |
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| Measure | Description | Time Frame |
|---|---|---|
| Difference in serum ADMA level between acute kidney injury and renal recovery | participants will be followed from the time of recruitment to the end of hospital stay, an expected average of 2 weeks | |
| Difference in serum SDMA level between acute kidney injury and renal recovery | participants will be followed from the time of recruitment to the end of hospital stay, an expected average of 2 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Associations between ADMA/SDMA serum level and all cause mortality | participants will be followed from the time of recruitment to the end of hospital stay, an expected average of 2 weeks | |
| Associations between ADMA/SDMA serum level and parameters of arterial stiffness |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with acute kidney injury in the University Hospital of Wuerzburg will be recruited on the wards and in the emergency unit when nephrologists are consulted.
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| Name | Affiliation | Role |
|---|---|---|
| Boris B Betz, Dr | Division of Nephrology Department of Medicine I University Hospital of Wuerzburg | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital of Wuerzburg | Würzburg | 97080 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17331245 | Background | Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, Levin A; Acute Kidney Injury Network. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care. 2007;11(2):R31. doi: 10.1186/cc5713. |
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| ID | Term |
|---|---|
| D058186 | Acute Kidney Injury |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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Blood and urine samples will be centrifuged. One ml aliquots of plasma, serum, urine and a whole blood sample will be stored at -80°C.
Parameters of arterial stiffness include augmentation index and pulse wave velocity
| participants will be followed from the time of recruitment to the end of hospital stay, an expected average of 2 weeks |
| Associations between ADMA/SDMA serum level and parameters of renal function | Parameters of renal function include serum creatinine and estimated Glomerular Filtration Rate (eGFR) | participants will be followed from the time of recruitment to the end of hospital stay, an expected average of 2 weeks |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |