COlchicine for Prevention of the Post-pericardiotomy Syndrome and Post-operative Atrial Fibrillation (COPPS-2 Trial)

COlchicine for Prevention of the Post-pericardiotomy Syndrome and Post-operative Atrial Fibrillation (COPPS-2 Trial).

This is a multicenter, double-blind, randomized trial to assess the efficacy and safety of colchicine for post-pericardiotomy syndrome prevention, post-operative effusions prevention, and post-operative atrial fibrillation prevention.

This is a multi center, double-blind, randomized trial to test the efficacy and safety of colchicine for prevention of post-pericardiotomy syndrome, post-operative effusions, and post-operative atrial fibrillation.

Inclusion Criteria:

• Age > 18years
• Candidate to cardiac surgery but cardiac transplantation
• Informed consent

Exclusion Criteria:

• Atrial fibrillation
• Candidate to cardiac transplantation
• Severe liver disease or elevation of serum transaminases (> 1.5 times the upper reference limit)
• Serum creatinine > 2.5 mg/dL
• Preoperative elevation of CK or known myopathy
• Known chronic intestinal diseases or blood dyscrasias
• Pregnancy, Lactation or Women of childbearing potential not protected by a contraception method
• Hypersensitivity to colchicine
• Treatment with colchicine for any cause