Study in Healthy Volunteers to Assess the Pharmacokinetics of Metformin Administered Alone and In Combination with Vandetanib

A Phase I, Open-label, Single-center Study to Assess the Pharmacokinetics of Metformin, an OCT2 Substrate, in Healthy Subjects When administered Alone and in Combination with a Single Oral Dose of Vandetanib (CAPRELSA) 800 mg

Inclusion Criteria:

• Healthy males or females aged 18 to 50 years with a weight of at least 50 kg and a body mass index between 18 and 30 kg/m2 inclusive.
• Females must have a negative pregnancy test at screening, must not be lactating and must be of non-childbearing potential.
• Volunteers will be wild type for the OCT2 gene (as tested for within the last 6 months prior to Day 1 in Period 1)

Exclusion Criteria:

• History or presence of gastrointestinal, hepatic, or renal disease or any medically significant disorder.
• History of or ongoing severe allergy/hypersensitivity to drugs with a similar chemical structure or class to vandetanib or metformin.
• Volunteers who smoke more than 5 cigarettes per day or are unable to refrain from smoking while resident in the study center.
• Known or suspected history of drug abuse.
• Screening supine blood pressure of greater than 140/90 mmHg and/or a resting heart rate of less than 45 beats per minute.
• Clinically significant current active skin disease (eg moderate to severe acne, psoriasis, eczema).
• Any positive result on screening for serum hepatitis B, surface antigen, hepatitis C antibody, and human immunodeficiency virus (HIV).