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Sleep after surgery has been found to be very distrubed immediately after major surgery. This is also seen after fast-track hip and knee replacement with length of stay of less than 3 days. Disturbed sleep has many adverse effects i.e. fatigue, possible hyperalgesia and decline in cognitive abilities.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Zolpidem | Experimental |
| |
| Placebo | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Zolpidem | Drug | The effect of Zolpidem 10 mg for the first night after surgery is asssessed using PSG |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in sleep time on the first postoperative night compared to preoperatively. | The primary endpoint is an evaluation of sleep stages on the first night postoperatively compared to preoperative measures for the same individual | first night postoperatively - 24 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Lene Krenk, MD | Rigshospitalet, Denmark | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gentofte Hospital | Gentofte Municipality | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24634631 | Derived | Krenk L, Jennum P, Kehlet H. Postoperative sleep disturbances after zolpidem treatment in fast-track hip and knee replacement. J Clin Sleep Med. 2014 Mar 15;10(3):321-6. doi: 10.5664/jcsm.3540. |
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| ID | Term |
|---|---|
| D000077334 | Zolpidem |
| ID | Term |
|---|---|
| D011725 | Pyridines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| Placebo | Drug | Pacebo tablet, blinded given on the first night after surgery |
|