| Primary | Ocular Itching at Duration of Action (16 Hours + 1 Hour Post-dose) | A treatment efficacy Conjunctival Allergen Challenge (CAC) was performed 16 hours + 1 hour after drop instillation. Ocular itching was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of ocular itching score over both eyes was analyzed. | | Posted | | Mean | Standard Deviation | units on a scale | | 3, 5, 7 minutes post-CAC | | | | ID | Title | Description |
|---|
| OG000 | AC-170 0.24% | AC-170 0.24%: 1 drop in each eye at 2 separate times during a 14 day period | | OG001 | AC-170 0% | AC-170 0%: 1 drop in each eye at 2 separate times during a 14 day period |
| | | Title | Denominators | Categories |
|---|
| 3 minutes post-CAC | | | Title | Measurements |
|---|
| - OG0001.71± 0.886
- OG0012.34± 0.720
|
| | 5 minutes post-CAC | | |
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| Primary | Ocular Itching at Onset of Action (15 Minutes Post-dose) | A treatment efficacy CAC was performed 15 minutes after drop instillation. Ocular itching was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of ocular itching score over both eyes was analyzed. | | Posted | | Mean | Standard Deviation | units on a scale | | 3, 5, 7 minutes post-CAC | | | | ID | Title | Description |
|---|
| OG000 | AC-170 0.24% | AC-170 0.24%: 1 drop in each eye at 2 separate times during a 14 day period | | OG001 | AC-170 0% | AC-170 0%: 1 drop in each eye at 2 separate times during a 14 day period |
| |
| Primary | Conjunctival Redness at Duration of Action (16 Hours + 1 Hour Post-dose) | A treatment efficacy CAC was performed 16 hours + 1 hour after drop instillation. Conjunctival Redness was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of conjunctival redness score over both eyes was analyzed. | | Posted | | Mean | Standard Deviation | units on a scale | | 7, 15, 20 minutes post-CAC | | | | ID | Title | Description |
|---|
| OG000 | AC-170 0.24% | AC-170 0.24%: 1 drop in each eye at 2 separate times during a 14 day period | | OG001 | AC-170 0% | AC-170 0%: 1 drop in each eye at 2 separate times during a 14 day period |
| |
| Primary | Conjunctival Redness at Onset of Action (15 Minutes Post-dose) | A treatment efficacy CAC was performed 15 minutes after drop instillation. Conjunctival Redness was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of conjunctival redness score over both eyes was analyzed. | | Posted | | Mean | Standard Deviation | units on a scale | | 7, 15, 20 minutes post-CAC | | | | ID | Title | Description |
|---|
| OG000 | AC-170 0.24% | AC-170 0.24%: 1 drop in each eye at 2 separate times during a 14 day period | | OG001 | AC-170 0% | AC-170 0%: 1 drop in each eye at 2 separate times during a 14 day period |
| |
| Secondary | Ciliary Redness at Duration of Action (16 Hours + 1 Hour Post-dose) | A treatment efficacy CAC was performed 16 hours + 1 hour after drop instillation. Ciliary Redness was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of ciliary redness score over both eyes was analyzed. | Intent to Treat (ITT) with observed data only. | Posted | | Mean | Standard Deviation | units on a scale | | 7, 15, 20 minutes post-CAC | | | | ID | Title | Description |
|---|
| OG000 | AC-170 0.24% | AC-170 0.24%: 1 drop in each eye at 2 separate times during a 14 day period | | OG001 | AC-170 0% | AC-170 0%: 1 drop in each eye at 2 separate times during a 14 day period |
| |
| Secondary | Ciliary Redness at Onset of Action (15 Minutes Post-dose) | A treatment efficacy CAC was performed 15 minutes after drop instillation. Ciliary Redness was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of ciliary redness score over both eyes was analyzed. | Intent to Treat (ITT) with observed data only. | Posted | | Mean | Standard Deviation | units on a scale | | 7, 15, 20 minutes post-CAC | | | | ID | Title | Description |
|---|
| OG000 | AC-170 0.24% | AC-170 0.24%: 1 drop in each eye at 2 separate times during a 14 day period | | OG001 | AC-170 0% | AC-170 0%: 1 drop in each eye at 2 separate times during a 14 day period |
| |
| Secondary | Episcleral Redness at Duration of Action (16 Hours + 1 Hour Post-dose) | A treatment efficacy CAC was performed 16 hours + 1 hour after drop instillation. Episcleral Redness was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of episcleral redness score over both eyes was analyzed. | Intent to Treat (ITT) with observed data only. | Posted | | Mean | Standard Deviation | units on a scale | | 7, 15, 20 minutes post-CAC | | | | ID | Title | Description |
|---|
| OG000 | AC-170 0.24% | AC-170 0.24%: 1 drop in each eye at 2 separate times during a 14 day period | | OG001 | AC-170 0% | AC-170 0%: 1 drop in each eye at 2 separate times during a 14 day period |
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| Secondary | Episcleral Redness at Onset of Action (15 Minutes Post-dose) | A treatment efficacy CAC was performed 15 minutes after drop instillation. Episcleral Redness was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of episcleral redness score over both eyes was analyzed. | Intent to Treat (ITT) with observed data only. | Posted | | Mean | Standard Deviation | units on a scale | | 7, 15, 20 minutes post-CAC | | | | ID | Title | Description |
|---|
| OG000 | AC-170 0.24% | AC-170 0.24%: 1 drop in each eye at 2 separate times during a 14 day period | | OG001 | AC-170 0% | AC-170 0%: 1 drop in each eye at 2 separate times during a 14 day period |
| |
| Secondary | Chemosis at Duration of Action (16 Hours + 1 Hour Post-dose) | A treatment efficacy CAC was performed 16 hours + 1 hour after drop instillation. Chemosis was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of chemosis score over both eyes was analyzed. | Intent to Treat (ITT) with observed data only. | Posted | | Mean | Standard Deviation | units on a scale | | 7, 15, 20 minutes post-CAC | | | | ID | Title | Description |
|---|
| OG000 | AC-170 0.24% | AC-170 0.24%: 1 drop in each eye at 2 separate times during a 14 day period | | OG001 | AC-170 0% | AC-170 0%: 1 drop in each eye at 2 separate times during a 14 day period |
| |
| Secondary | Chemosis at Onset of Action (15 Minutes Post-dose) | A treatment efficacy CAC was performed 15 minutes after drop instillation. Chemosis was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of chemosis score over both eyes was analyzed. | Intent to Treat (ITT) with observed data only. | Posted | | Mean | Standard Deviation | units on a scale | | 7, 15, 20 minutes post-CAC | | | | ID | Title | Description |
|---|
| OG000 | AC-170 0.24% | AC-170 0.24%: 1 drop in each eye at 2 separate times during a 14 day period | | OG001 | AC-170 0% | AC-170 0%: 1 drop in each eye at 2 separate times during a 14 day period |
| |
| Secondary | Eyelid Swelling at Duration of Action (16 Hours + 1 Hour Post-dose) | A treatment efficacy CAC was performed 16 hours + 1 hour after drop instillation. Eyelid swelling was assessed by the patient on a 0-3 scale (0=none to 3=severe). Average of eyelid swelling score over both eyes was analyzed. | Intent to Treat (ITT) with observed data only. | Posted | | Mean | Standard Deviation | units on a scale | | 7, 15, 20 minutes post-CAC | | | | ID | Title | Description |
|---|
| OG000 | AC-170 0.24% | AC-170 0.24%: 1 drop in each eye at 2 separate times during a 14 day period | | OG001 | AC-170 0% | AC-170 0%: 1 drop in each eye at 2 separate times during a 14 day period |
| |
| Secondary | Eyelid Swelling at Onset of Action (15 Minutes Post-dose) | A treatment efficacy CAC was performed 15 minutes after drop instillation. Eyelid swelling was assessed by the patient on a 0-3 scale (0=none to 3=severe). Average of eyelid swelling score over both eyes was analyzed. | Intent to Treat (ITT) with observed data only. | Posted | | Mean | Standard Deviation | units on a scale | | 7, 15, 20 minutes post-CAC | | | | ID | Title | Description |
|---|
| OG000 | AC-170 0.24% | AC-170 0.24%: 1 drop in each eye at 2 separate times during a 14 day period | | OG001 | AC-170 0% | AC-170 0%: 1 drop in each eye at 2 separate times during a 14 day period |
| |
| Secondary | Tearing at Duration of Action (16 Hours + 1 Hour Post-dose) | A treatment efficacy CAC was performed 16 hours + 1 hour after drop instillation. Tearing was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of tearing score over both eyes was analyzed. | Intent to Treat (ITT) with observed data only. | Posted | | Mean | Standard Deviation | units on a scale | | 7, 15, 20 minutes post-CAC | | | | ID | Title | Description |
|---|
| OG000 | AC-170 0.24% | AC-170 0.24%: 1 drop in each eye at 2 separate times during a 14 day period | | OG001 | AC-170 0% | AC-170 0%: 1 drop in each eye at 2 separate times during a 14 day period |
| |
| Secondary | Tearing at Onset of Action (15 Minutes Post-dose) | A treatment efficacy CAC was performed 15 minutes after drop instillation. Tearing was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of tearing score over both eyes was analyzed. | Intent to Treat (ITT) with observed data only. | Posted | | Mean | Standard Deviation | units on a scale | | 7, 15, 20 minutes post-CAC | | | | ID | Title | Description |
|---|
| OG000 | AC-170 0.24% | AC-170 0.24%: 1 drop in each eye at 2 separate times during a 14 day period | | OG001 | AC-170 0% | AC-170 0%: 1 drop in each eye at 2 separate times during a 14 day period |
| |
| Secondary | Rhinorrhea at Duration of Action (16 Hours +1 Hour Post-dose) | A treatment efficacy CAC was performed 16 hours + 1 hour after drop instillation. Rhinorrhea was assessed by the patient on a 0-4 scale (0=none to 4=severe). Rhinorrhea score for each time point was analyzed. | Intent to Treat (ITT) with observed data only. | Posted | | Mean | Standard Deviation | units on a scale | | 7, 15, 20 minutes post-CAC | | | | ID | Title | Description |
|---|
| OG000 | AC-170 0.24% | AC-170 0.24%: 1 drop in each eye at 2 separate times during a 14 day period | | OG001 | AC-170 0% | AC-170 0%: 1 drop in each eye at 2 separate times during a 14 day period |
| |
| Secondary | Rhinorrhea at Onset of Action (15 Minutes Post-dose) | A treatment efficacy CAC was performed 15 minutes after drop instillation. Rhinorrhea was assessed by the patient on a 0-4 scale (0=none to 4=severe). Rhinorrhea score for each time point was analyzed. | Intent to Treat (ITT) with observed data only. | Posted | | Mean | Standard Deviation | units on a scale | | 7, 15, 20 minutes post-CAC | | | | ID | Title | Description |
|---|
| OG000 | AC-170 0.24% | AC-170 0.24%: 1 drop in each eye at 2 separate times during a 14 day period | | OG001 | AC-170 0% | AC-170 0%: 1 drop in each eye at 2 separate times during a 14 day period |
| |
| Secondary | Nasal Pruritis at Duration of Action (16 Hours + 1 Hour Post-dose) | A treatment efficacy CAC was performed 16 hours + 1 hour after drop instillation. Nasal Pruritus was assessed by the patient on a 0-4 scale (0=none to 4=severe). Nasal Pruritus score for each time point was analyzed. | Intent to Treat (ITT) with observed data only. | Posted | | Mean | Standard Deviation | units on a scale | | 7, 15, 20 minutes post-CAC | | | | ID | Title | Description |
|---|
| OG000 | AC-170 0.24% | AC-170 0.24%: 1 drop in each eye at 2 separate times during a 14 day period | | OG001 | AC-170 0% | AC-170 0%: 1 drop in each eye at 2 separate times during a 14 day period |
| |
| Secondary | Nasal Pruritis at Onset of Action (15 Minutes Post-dose) | A treatment efficacy CAC was performed 15 minutes after drop instillation. Nasal Pruritus was assessed by the patient on a 0-4 scale (0=none to 4=severe). Nasal Pruritus score for each time point was analyzed. | Intent to Treat (ITT) with observed data only. | Posted | | Mean | Standard Deviation | units on a scale | | 7, 15, 20 minutes post-CAC | | | | ID | Title | Description |
|---|
| OG000 | AC-170 0.24% | AC-170 0.24%: 1 drop in each eye at 2 separate times during a 14 day period | | OG001 | AC-170 0% | AC-170 0%: 1 drop in each eye at 2 separate times during a 14 day period |
| |
| Secondary | Ear or Palate Pruritis at Duration of Action (16 Hours + 1 Hour Post-dose) | A treatment efficacy CAC was performed 16 hours + 1 hour after drop instillation. Ear or Palate Pruritus was assessed by the patient on a single 0-4 scale (0=none to 4=severe). Ear or Palate Pruritus score for each time point was analyzed. | Intent to Treat (ITT) with observed data only. | Posted | | Mean | Standard Deviation | units on a scale | | 7, 15, 20 minutes post-CAC | | | | ID | Title | Description |
|---|
| OG000 | AC-170 0.24% | AC-170 0.24%: 1 drop in each eye at 2 separate times during a 14 day period | | OG001 | AC-170 0% | AC-170 0%: 1 drop in each eye at 2 separate times during a 14 day period |
| |
| Secondary | Ear or Palate Pruritis at Onset of Action (15 Minutes Post-dose) | A treatment efficacy CAC was performed 15 minutes after drop instillation. Ear or Palate Pruritus was assessed by the patient on a single 0-4 scale (0=none to 4=severe). Ear or Palate Pruritus score for each time point was analyzed. | Intent to Treat (ITT) with observed data only. | Posted | | Mean | Standard Deviation | units on a scale | | 7, 15, 20 minutes post-CAC | | | | ID | Title | Description |
|---|
| OG000 | AC-170 0.24% | AC-170 0.24%: 1 drop in each eye at 2 separate times during a 14 day period | | OG001 | AC-170 0% | AC-170 0%: 1 drop in each eye at 2 separate times during a 14 day period |
| |
| Secondary | Nasal Congestion at Duration of Action (16 Hours + 1 Hour Post-dose) | A treatment efficacy CAC was performed 16 hours + 1 hour after drop instillation. Nasal Congestion was assessed by the patient on a 0-4 scale (0=none to 4=severe). Nasal Congestion score for each time point was analyzed. | Intent to Treat (ITT) with observed data only. | Posted | | Mean | Standard Deviation | units on a scale | | 7, 15, 20 minutes post-CAC | | | | ID | Title | Description |
|---|
| OG000 | AC-170 0.24% | AC-170 0.24%: 1 drop in each eye at 2 separate times during a 14 day period | | OG001 | AC-170 0% | AC-170 0%: 1 drop in each eye at 2 separate times during a 14 day period |
| |
| Secondary | Nasal Congestion at Onset of Action (15 Minutes Post-dose) | A treatment efficacy CAC was performed 15 minutes after drop instillation. Nasal Congestion was assessed by the patient on a 0-4 scale (0=none to 4=severe). Nasal Congestion score for each time point was analyzed. | Intent to Treat (ITT) with observed data only. | Posted | | Mean | Standard Deviation | units on a scale | | 7, 15, 20 minutes post-CAC | | | | ID | Title | Description |
|---|
| OG000 | AC-170 0.24% | AC-170 0.24%: 1 drop in each eye at 2 separate times during a 14 day period | | OG001 | AC-170 0% | AC-170 0%: 1 drop in each eye at 2 separate times during a 14 day period |
| |
| Secondary | Number of Participants With At Least One of the Nasal Symptoms Present (Rhinorrhea + Nasal Pruritus + Ear or Palate Pruritus + Nasal Congestion) at Duration of Action (16 Hours + 1 Hour Post-dose) | A treatment efficacy CAC was performed 16 hours + 1 hour after drop instillation. For Nasal Composite Score the Total Composite Score ranges from 0 to 16, higher scores represent greater severity. Patients needed to have at least one of the nasal symptoms present (Rhinorrhea + Nasal Pruritus + Ear or Palate Pruritus + Nasal Congestion) each symptom was assessed by the patient on a 0-4 scale (0=none to 4=severe). Nasal Composite score for each time point was analyzed. | Intent to Treat (ITT) with observed data only. | Posted | | Number | | %participants with at least 1 nasal symp | | 7, 15, 20 minutes post-CAC | | | | ID | Title | Description |
|---|
| OG000 | AC-170 0.24% | AC-170 0.24%: 1 drop in each eye at 2 separate times during a 14 day period | | OG001 | AC-170 0% | AC-170 0%: 1 drop in each eye at 2 separate times during a 14 day period |
| |
| Secondary | Number of Participants With At Least One of the Nasal Symptoms Present (Rhinorrhea + Nasal Pruritus + Ear or Palate Pruritus + Nasal Congestion) at Onset of Action (15 Minutes Post-dose) | A treatment efficacy CAC was performed 15 minutes after drop instillation. For Nasal Composite Score the Total Composite Score ranges from 0 to 16, higher scores represent greater severity. Patients needed to have at least one of the nasal symptoms present (Rhinorrhea + Nasal Pruritus + Ear or Palate Pruritus + Nasal Congestion) each symptom was assessed by the patient on a 0-4 scale (0=none to 4=severe). Nasal Composite score for each time point was analyzed. | Intent to Treat (ITT) with observed data only. | Posted | | Number | | %participants with at least 1 nasal symp | | 7, 15, 20 minutes post-CAC | | | | ID | Title | Description |
|---|
| OG000 | AC-170 0.24% | AC-170 0.24%: 1 drop in each eye at 2 separate times during a 14 day period | | OG001 | AC-170 0% | AC-170 0%: 1 drop in each eye at 2 separate times during a 14 day period |
| |
| Secondary | Tolerability of Study Medication at Visit 3A | Tolerability was assessed upon instillation of study medication, at 1 minute and 2 minutes post study medication instillation. Drop comfort was assessed using a 0-to 10 scale where 0=very comfortable and 10=very uncomfortable. | | Posted | | Mean | Standard Deviation | units on a scale | | upon instillation, 1 minute and 2 minutes post instillation | | | | ID | Title | Description |
|---|
| OG000 | AC-170 0.24% | AC-170 0.24%: 1 drop in each eye at 2 separate times during a 14 day period | | OG001 | AC-170 0% | AC-170 0%: 1 drop in each eye at 2 separate times during a 14 day period |
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