The purpose of this study is to look for low levels of oxygen (hypoxia) in your cervix cancer using a special x-ray test called a positron emission tomography (PET)scan. Hypoxia may have an effect on how cervix cancer grows and responds to treatments like radiotherapy and chemotherapy. Doctors at Princess Margaret Hospital have measured hypoxia in over 300 patients. The use of PET scans to measure hypoxia may be better and simpler than the methods used previously.

Inclusion Criteria:

• Age ≥18 years
• Histologic diagnosis of squamous cell carcinoma, adenocarcinoma or adenosquamous carcinoma of the cervix
• TNM (7th edition) cT1-4, N0-1, M0-1
• Intention to treat using radiotherapy with or without concurrent cisplatin chemotherapy according to the current treatment policies of the PMH Gynecology Group
• No cytotoxic anti-cancer therapy for cervix cancer prior to study entry
• A negative urine or serum pregnancy test within the two week interval immediately prior to PET-CT imaging, in women of child-bearing age
• Ability to provide written informed consent to participate in the study

Exclusion Criteria:

• Prior complete or partial hysterectomy
• Carcinoma of the cervical stump
• Inability to lie supine for more than 30 minutes
• Patients taking the drug disulfuram (Antabuse)