EEG Studies of Induction and Recovery From Propofol Induced General Anesthesia

Electroencephalogram Studies of Induction and Recovery From Propofol Induced General Anesthesia

The purpose of this study is to investigate how the commonly used anesthetic drug propofol works in the brain to produce loss of consciousness. While under general anesthesia your brain waves will be measured using electroencephalogram (EEG). On a separate day, the patient's brain will be imaged using magnetic resonance imaging (MRI).

Inclusion Criteria:

• Healthy, non-smoking male and female volunteers, ages 18-36 with normal body weight.
• American Society of Anesthesiologists (ASA) physical status I

Exclusion Criteria:

• History of head trauma
• Surgical aneurysm clips
• Cardiac pacemaker
• Prosthetic heart valve
• Neurostimulator
• Implanted pumps
• Cochlear implants
• Metal rods, plates
• Screws
• Intrauterine device
• Hearing aid
• Dentures (which might create NMR artifacts)
• Metal injury to eyes