Antibiotic Concentrations Among Critically Ill Patients

Antibiotic Concentrations Among Critically Ill Patients

The primary objective of the DALI study is to compare antibiotic concentrations in patient blood samples with bacteriological objectives associated with maximum bactericidal activity. The antibiotics studied are certain lactams and glycopeptides.

Inclusion Criteria:

• The patient (or his/her "trusted representative") must have given his/her informed and signed consent
• Antibiotic treatment is administered with beta-lactams or glycopeptides administered continuously or intermittently (Can be of the following: Amoxicillin-clavulanic acid, ampicillin, piperacillin-tazobactam, penicillin G, flucloxacillin, dicloxacillin, cloxacillin, cefazolin, ceftazidime, ceftriaxone, cefepime, meropenem, imipenem, doripenem, ertapenem; Vancomycin, teicoplanin).
• A vein or artery catheter is established to facilitate blood sampling (arterial catheter is preferred)

Exclusion Criteria:

• None of the above-mentioned antibiotics are administered
• Impossible to establish venous or arterial catheter
• Consent not given
• Patient is pregnant, parturient or breastfeeding
• The patient is under tutorship or curatorship
• The patient is participating in another study