Effect of Pentoxifylline on Tight Junctions (TJs) of Intestinal Mucosa in Patients With Irritable Bowel Syndrome(IBS)

Effect of Pentoxifylline on Tight Junctions of Intestinal Mucosa in Patients With Irritable Bowel Syndrome

The purpose of this study is to determine the therapeutics effectiveness of oral pentoxifylline treatment in patients with IBS.

Disruption of the intestinal epithelial barrier is part of the pathophysiology of IBS favoring immune activation present in the mucosa of these patients and the development of symptoms in IBS. To evaluate the effect of treatment with pentoxifylline (PTX) in patients with IBS related to clinical response and modulation of the components of the epithelial barrier at the level of intestinal mucosa.

Inclusion Criteria:

• Age between 18 and 65 years old
• Most of the patient with IBS will be chose between the patients who go to Digestive System ambulatory external medical office from our Center.
• Be studied and with clinical monitoring al least 6 months before be included.
• Fulfill with Roma III Criteria for IBS (Gastroenterology 2006;130:1377-90) with moderate-severe seriousness according to Modification Francis Scale

Exclusion Criteria:

• 2 weeks before colon biopsia, any patient cann´t take salicylates, NSAID, antibiotics,anticholinergics,opiates or any other medication / product for asintomatic treatment of diarrea.
• 3 months before colon biopsia, any patient cann´t take medicaments as corticoides, antihistamines or immunosuppressive
• 6 months before colon biopsia, any patient cann´t recive radiotherapy or chemotherapy.
• Pentoxifilina Alergic Reactions
• Pregnants
• Grave kidney failure
• Grave Hepatic failure
• Menthal or legal disability to sign the consent