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| Name | Class |
|---|---|
| University of Colorado, Denver | OTHER |
| International Atomic Energy Agency | OTHER_GOV |
| Bill and Melinda Gates Foundation | OTHER |
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The broad objective is to improve zinc status in older infants and young children who are at risk of zinc deficiency because of combination of inadequate dietary zinc intake and high rates of diarrhea. As a sub-study within larger RCT using zinc fortified Sprinkles, the proposed study will measure the amount of zinc absorbed from a test meal of typical unfortified complementary foods consumed by Pakistani infants, or the same complementary foods fortified by the addition of the Zn-containing Sprinkle.
In the nested study we aim to measure from a subgroup of recruited children in the main study, the amount of zinc absorbed from typical unfortified complementary foods consumed by Pakistani infants, and compare it with the same complementary food fortified by the addition of the Zn-containing Sprinkles and multi vitamins. Since EZP Exchangeable Zinc Pool is considered to be the gold standard for estimation of the actual concentration of zinc in the plasma that is readily available for cellular function, we would also calculate the EZP in this subset of samples.
The specific aim of the nested study will :
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group B | subjects in this group will receive Micronutrient Supplements only. | ||
| Group C | Subjects in this Group will receive Micronutrient Supplements plus Zinc. |
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| Measure | Description | Time Frame |
|---|---|---|
| Exchangeable Zn Pool Size and Zn Absorption from Sprinkles and Traditional Foods in Pakistani Infants/Toddlers | Compare size of exchangeable Zn pool (EZP) for subjects who have been randomized to receive multi-micronutrient Sprinkle (MN) only with those who were randomized to (MN+Zn ) . Compare plasma zinc levels between the two groups Measure the fractional absorption of zinc between the two groups | one year |
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Inclusion Criteria:
Exclusion Criteria:
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Infants between the ages of 9 and 12 months
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| Name | Affiliation | Role |
|---|---|---|
| Sajid B Soofi, MBBS, FCPS | Aga Khan University | Principal Investigator |
| Shabina Ariff, MBBS, FCPS | Aga Khan University | Study Director |
| Zulfiqar A Bhutta, PhD | Aga Khan University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bilal Colony | Karachi | Sindh | 75300 | Pakistan |
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| ID | Term |
|---|---|
| D044342 | Malnutrition |
| ID | Term |
|---|---|
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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