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The purpose of this study is to compare conventional PET/CT scan performed 1 hour after injection of the radioactive tracer FDG (PET/CT[1]) with PET/CT performed after 3 hours (PET/CT[3]) in a group of patients with biopsy verified lung cancer or high suspicion of lung cancer after initial work-up (chest x-ray and CT of thorax/upper abdomen), who are potentially operable.
The investigators also want to:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| lung cancer or high suspicion of lung cancer | After initial work-up (chest x-ray, CT of thorax and upper abdomen, spirometry) found to have surgically resectable lung cancer |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dual FDG-PET/CT | Other | Conventional FDG-PET/CT preformed after 1 hour and additional PET/CT 3 hours after injection |
|
| Measure | Description | Time Frame |
|---|---|---|
| Sensitivity, specificity and accuracy | To find the sensitivity, specificity and accuracy in PET/CT 1h and 3 h in the staging of lung cancer (N-/M-stage). Our gold standard is pathology, when not possible - follow-up | After staging or 1 year of follow up |
| Measure | Description | Time Frame |
|---|---|---|
| Occurence of relapse | • To compare SUVmax, RI, tumor/liver ratio, GLUT1 and G-6-Pase with the occurrence of relapse within a year after curative surgery | 1 year follow up after surgery |
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Inclusion Criteria:
Exclusion Criteria:
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Pt. referred to The Department of Pulmonary Medicine, Odense University Hospital or The Department of Medicine, Hospital of Southern Denmark, Sønderborg with suspicion of lung cancer
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mie H Vilstrup, MD, Principal investigor | Contact | +45 2159 3008 | mie.holm.vilstrup@rsyd.dk | |
| Poul Flemming Høilund-Carlsen, MD, DMSc, Professor | Contact | +45 3016 1445 | pfhc@rsyd.dk |
| Name | Affiliation | Role |
|---|---|---|
| Mie H Vilstrup, MD | Odense University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Pulmonary Medicine | Recruiting | Odense C | Fünen | 5000 | Denmark |
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| ID | Term |
|---|---|
| D008175 | Lung Neoplasms |
| ID | Term |
|---|---|
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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Fresh frozen sample of primary lung cancer tumor
| D008171 |
| Lung Diseases |
| D012140 | Respiratory Tract Diseases |