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The purpose of this study is to define early urinary biomarkers for diagnosis and prognosis of Renal Cell Carcinoma (RCC) with subsequent development of reliable, cost-effective, screening techniques.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 | Enrollment of surgical patients at Barnes Jewish Hospital (BJH) with a presumptive diagnosis of RCC and planned nephrectomy or partial nephrectomy. | ||
| Group 2 | Surgical patients at BJH with non urological cancers | ||
| Group 3 | Surgical patients at BJH with a presumptive diagnosis of RCC and planned nephrectomy or partial nephrectomy | ||
| Group 4 | Surgical patients at BJH with non urological cancers | ||
| Group 5 | Healthy volunteers with no history of cancer or renal disease | ||
| Group 6 | Patients at BJH/Washington University School of Medicine under post procedure surveillance for RCC recurrence and patients under treatment for metastatic disease. | ||
| Group 7 | Patients with a presumptive diagnosis of bladder cancer or prostate cancer |
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| Measure | Description | Time Frame |
|---|---|---|
| evaluation of novel bio markers | The overall objective of our study is to find and evaluate additional novel biomarkers, predictive of disease, that are present and measurable in whole urine of patients undergoing surgery for renal cancer. | 5 years |
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Inclusion Criteria:
Exclusion Criteria:
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Patients scheduled to have full or partial kidney removal surgery (possibly because of kidney cancer).
Patients scheduled to have a procedure because you may have bladder or prostate cancer.
Patients scheduled to have some other type of surgery (non-urological). Healthy volunteers
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| Name | Affiliation | Role |
|---|---|---|
| Jerry Morrissey, PhD | Washington University School of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Washington University School of Medicine | St Louis | Missouri | 63110 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31668633 | Derived | Hu R, Gupta R, Wang Z, Wang C, Sun H, Singamaneni S, Kharasch ED, Morrissey JJ. Bioplasmonic paper-based assay for perilipin-2 non-invasively detects renal cancer. Kidney Int. 2019 Dec;96(6):1417-1421. doi: 10.1016/j.kint.2019.08.020. Epub 2019 Sep 3. |
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| ID | Term |
|---|---|
| D002292 | Carcinoma, Renal Cell |
| ID | Term |
|---|---|
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
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| D009369 | Neoplasms |
| D007680 | Kidney Neoplasms |
| D014571 | Urologic Neoplasms |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052801 | Male Urogenital Diseases |