The objectives of this study are

• To determine PK of propofol in bariatric patients
• To identify the physiological variables that induce propofol PK changes in bariatric patients, when compared to a normal-weight population.
• To define context-sensitive half-time profiles for propofol in bariatric patients.

Inclusion Criteria:

• Consecutive patients admitted to the Aker University Hospital, scheduled for general or bariatric surgery,
• Both genders. Female subjects of childbearing potential must be using adequate contraception (i.e. using oral or IM contraception or an IUCD) and must have a negative pregnancy test (urine beta-HCG).
• Aged 18 - 60 years, both inclusive
• Body mass index (BMI) ≥ 20 kg/m2
• Written informed consent

Exclusion Criteria:

• Patients that are considered not to tolerate a standard dose of propofol administered as a bolus.
• Known hypersensitivity to propofol or its ingredients (soy, lecithin, glycerol, oil acid)
• Known hypersensitivity to any of the anesthetic agents to be used
• Pregnant women
• Lactating women