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This is a noninterventional observational study lead amongst psychiatrists, to assess the the overall status of schizophrenic outpatients with affective symptoms treated with atypical antipsychotics.
Atypical antipsychotics in the treatment of affective symptoms of schizophrenia in Hungary
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Schizophrenic outpatients with affective symptoms. |
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| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline on clinical global impression scale up to 6 months of schizophrenic outpatients with affective symptoms. | The Clinical Global Impression Scale (CGI) is a brief clinician-rated instrument. The CGI severity of illness measure (CGI-S) is rated from 1 (normal, not at all ill) to 7 (among the most extremely ill patients). The CGI global improvement measure (CGI-I) is rated from 1 (very much improved) to 7 (very much worse). "0" stands for "not assessed". Means and standard deviations (SD) for CGI-S(baseline), CGI-S (1.visit) CGI-S (2.visit) and for CGI-I will be calculated. | 3 and 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Description of the relation between and the change of affective symptoms and overall clinical status. | 3 and 6 months | |
| Assessment of the efficacy of different atypical antipsychotics in the treatment of schizophrenia with affective symptoms measured by the difference in CGI-S (CGI severity of illness measure) and CGI-I (CGI global improvement measure). |
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Inclusion Criteria:
Exclusion Criteria:
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Schizophrenic outpatients above 18 years of age with affective symptoms.
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| Name | Affiliation | Role |
|---|---|---|
| Attila Nemeth, MD PHD | National Center of Psychiatry | Principal Investigator |
| Lilla Szabo, MD | AstraZeneca | Study Chair |
| Alexandra Heringh, MD | AstraZeneca | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Research Site | Agárd | Hungary | ||||
| Research Site |
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The Clinical Global Impression Scale (CGI) is a brief clinician-rated instrument. The CGI severity of illness measure (CGI-S) is rated from 1 (normal, not at all ill) to 7 (among the most extremely ill patients). The CGI global improvement measure (CGI-I) is rated from 1 (very much improved) to 7 (very much worse). "0" stands for "not assessed". |
| From baseline up to 6 months |
| Assessment of the efficacy of different atypical antipsychotics in the treatment of schizophrenia with affective symptoms measured by the difference in Raskin Scale. | Raskin scale is rated from 1 not at all to 5 very much , in three aspects: verbal report, behaviour, secondary symptoms of depression. Above 9 (the sum points) is considered moderate depression. | From baseline up to 6 months |
| Baja |
| Hungary |
| Research Site | Barcs | Hungary |
| Research Site | Berettyóújfalu | Hungary |
| Research Site | Bicske | Hungary |
| Research Site | Bonyhád | Hungary |
| Research Site | Budapest | Hungary |
| Research Site | Cegléd | Hungary |
| Research Site | Debrecen | Hungary |
| Research Site | Dombóvár | Hungary |
| Research Site | Dunaújváros | Hungary |
| Research Site | Esztergom | Hungary |
| Research Site | Érd | Hungary |
| Research Site | Gyöngyös | Hungary |
| Research Site | Győr | Hungary |
| Research Site | Gyula | Hungary |
| Research Site | Hatvan | Hungary |
| Research Site | Heves | Hungary |
| Research Site | Hódmezővásárhely | Hungary |
| Research Site | Izsófalva | Hungary |
| Research Site | Jánoshalma | Hungary |
| Research Site | Jászberény | Hungary |
| Research Site | Kalocsa | Hungary |
| Research Site | Karcag | Hungary |
| Research Site | Kecskemét | Hungary |
| Research Site | Kiskunhalas | Hungary |
| Research Site | Kiskunmajsa | Hungary |
| Research Site | Kistarcsa | Hungary |
| Research Site | Kistokaj | Hungary |
| Research Site | Makó | Hungary |
| Research Site | Miskolc | Hungary |
| Research Site | Mosonmagyaróvár | Hungary |
| Research Site | Nagykanizsa | Hungary |
| Research Site | Nagykálló | Hungary |
| Research Site | Oroszlány | Hungary |
| Research Site | Pápa | Hungary |
| Research Site | Pécs | Hungary |
| Research Site | Pomáz | Hungary |
| Research Site | Salgótarján | Hungary |
| Research Site | Sátoraljaújhely | Hungary |
| Research Site | Sopron | Hungary |
| Research Site | Szeged | Hungary |
| Research Site | Szeghalom | Hungary |
| Research Site | Szekszárd | Hungary |
| Research Site | Szentendre | Hungary |
| Research Site | Szentes | Hungary |
| Research Site | Székesfehérvár | Hungary |
| Research Site | Szigetszentmiklós | Hungary |
| Research Site | Szolnok | Hungary |
| Research Site | Szombathely | Hungary |
| Research Site | Tószeg | Hungary |
| Research Site | Vác | Hungary |
| Research Site | Veszprém | Hungary |
| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| D000342 | Affective Symptoms |
| D003863 | Depression |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
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