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There is a constant exchange between the gut epithelium and lumen, including microbial interplay. The aim of this study was to investigate dietary test products on inflammatory proliferation markers in the gut, and thereby if the products had positive effects in the gut as well as in other parts of the body.
The hypothesis was that the test products would reduce the inflammatory and proliferation activity of the gut epithelium by fermentation of normal food products and by converting dietary phenolic compounds into anti-inflammatory substances.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Probiotics_Lactobacillus | Experimental | Intervention (2 weeks) with a strain of Lactobacillus |
|
| Probiotics_Bifidobacterium | Experimental | Intervention (2 weeks) of daily supplementation of a probiotic strain of Bifidobacterium. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lactobacillus | Dietary Supplement | Intervention (2 weeks) with a strain of Lactobacillus |
|
| Measure | Description | Time Frame |
|---|---|---|
| Reactivity of rectal mucosa | to study the reactivity of rectal mucosa after a standardized inflammatory insult before and after treatment with probiotics | after 2 weeks intervention |
| Measure | Description | Time Frame |
|---|---|---|
| influence on immune system | to study the influence on systemic leukocytes and regulatory T cells | after 2 weeks intervention |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Bengt Jeppson, MD, PhD | Region Skane | Study Director |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35247974 | Derived | Stene C, Rome A, Palmquist I, Linninge C, Molin G, Ahrne S, Johnson LB, Jeppsson B. Administration of probiotics to healthy volunteers: effects on reactivity of intestinal mucosa and systemic leukocytes. BMC Gastroenterol. 2022 Mar 5;22(1):100. doi: 10.1186/s12876-022-02185-1. |
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| ID | Term |
|---|---|
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| C100843 | Lacteol |
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| Bifidobacterium | Dietary Supplement | Intervention (2 weeks) with a strain of Bifidobacterium |
|
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