Application of Citrate Dialysate in Chronic Haemodialysis

Application of Citrate Dialysate in Chronic Haemodialysis

Study investigating the safety and efficacy of the citrate dialysis solution compared to standard acetate dialysis solution. Use of citrate dialysis solution is not associated with a clinically relevant development of adverse events. It is hypothesized that citrate dialysate may provide a local anticoagulation effect in the dialyser improving removal of uremic toxins.

It is hypothesized that citrate dialysate may provide a local anticoagulation effect in the dialyser improving removal of uremic toxins. Study investigating the safety and efficacy of the citrate dialysis solution compared to standard acetate dialysis solution. Use of citrate dialysis solution is not associated with a clinically relevant development of adverse events.

Inclusion Criteria:

• signed informed consent
• patients of either sex aged ≥ 18 years
• stable chronic dialysis patients undergoing a 3x/week high-flux dialysis for at least three months
• patients without planned or predictable changes within diet, anticoagulation and medication regimen

Exclusion Criteria:

• pregnancy or lactation or woman in child bearing age without effective contraception
• planned surgeries or hospital stay within the next 9 weeks
• use of catheter as vascular access for dialysis
• severe comorbidities not allowing to follow the study protocol
• concomitant participation in another study
• previous participation in this study