Treatment of Hepatorenal Syndrome With Terlipressin Infusion Adjusted to Hemodynamic Response

Treatment of Hepatorenal Syndrome With Terlipressin Infusion Adjusted to Hemodynamic Response

Observe the effect of terlipressin on renal function in patients with SHR type I adjusting the dose based on hemodynamic response.

Inclusion Criteria:

• Patients with hepatorenal syndrome type 1.
• Signed informed consent.
• No exclusion criteria.
• At least 18 years old
• Negative pregnancy test in serum or urine in women of childbearing age, and agree to use adequate contraception since at least 14 days prior to the first dose of study drug until 14 days after the last.

Exclusion Criteria:

• Hepatocellular carcinoma: exclusion of patients with hepatocellular carcinoma who present more than 3 nodules, single nodule larger than 5 cm, tumor portal thrombosis or extrahepatic tumor spread.
• Active bacterial infection with symptoms of systemic inflammatory response (fever, tachycardia, tachypnea, hypotension, septic or blood count).
• Cardiac or respiratory failure clinically significant.
• Clinically significant peripheral artery disease.
• A history of ischemic heart disease.
• Hypersensitivity to terlipressin and / or albumin or any of the excipients.
• Pregnancy.
• Septic shock.
• Chronic renal failure.
• Women in lactation