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| Name | Class |
|---|---|
| Fundação de Amparo à Pesquisa do Estado de São Paulo | OTHER_GOV |
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The purpose of this study is to access whether shift workers (morning, afternoon or night) vaccinated against hepatitis A would have some humoral and cellular response impairment.
Sleep regulates immune functions. In this sense, we asked whether shift workers (morning, afternoon or night) vaccinated against hepatitis A would have some humoral and cellular response impairment. Men (18 to 55 years) will be recruited through different forms of media (electronic, newspapers, radio and magazines). The shift workers sleep pattern will be recorded polysomnographically. Subsequently, the volunteers will be underwent vaccination against hepatitis A (2 doses) and after 30, 60 and 90 days, blood samples will be collected to assess the humoral response in the experimental groups. The hormones prolactin, growth hormone, cortisol, adrenaline and noradrenaline will also be evaluated. Indeed, stimulations in culture will be conducted to assess the cellular response profile against the vaccination through the production assessment of IL-4, IFN-γ, IL-2 and TNF-α.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Shiftwork | Experimental | The comparison will consider nightworkers versus dayworkers. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vaccination against hepatitis A | Biological | Vaccination against hepatitis A (2 doses) into the deltoid muscle of the nondominant arm twice, i.e., at 0 and 6 months. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Antibodies against hepatitis A virus (anti-HAV) | Change in antibodies against hepatitis A virus (anti-HAV) production | Baseline, 30 days, 60 days and 90 days |
| Measure | Description | Time Frame |
|---|---|---|
| Intracellular cytokines | Change in intracellular IL-4, IFN-γ, IL-2 e TNF-α cytokine levels | Baseline, 30 days, 60 days and 90 days |
| Catecholamines | Change in cathecolamines levels |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Marco Tulio Mello, Associate Professor | Federal University of São Paulo | Study Director |
| Francieli Silva Ruiz, PhD | Federal University of São Paulo | Study Chair |
| Andrea Maculano, PhD | Federal University of São Paulo | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centro de Estudos em Psicobiologia e Exercicio _ CEPE | São Paulo | São Paulo | 04020050 | Brazil | ||
| Centro de Estudos em Psicobiologia e Exercicio - CEPE |
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| Label | URL |
|---|---|
| Fundação de Amparo à Pesquisa do Estado de São Paulo | View source |
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| No Intervention | Other | No Intervention |
|
| Baseline, 30 days, 60 days and 90 days |
| Prolactin | Change in prolactin levels | Baseline, 30 days, 60 days and 90 days |
| Growth hormone | Change in growth hormone levels | Baseline, 30 days, 60 days and 90 days |
| Cortisol | Change in cortisol levels | Baseline, 30 days, 60 days and 90 days |
| Sleep disorders | Assessment of sleep disorders | Baseline |
| São Paulo |
| 04020050 |
| Brazil |