The purpose of this study is to assess the effects of Metformin administered over two weeks on the peak plasma glucose concentrations following administration of BMS-754807.

Primary Purpose: Other - Protocol designed to evaluate pharmacodynamics following administration of two compounds

Inclusion Criteria:

• Healthy male and female subjects ages 18 to 55 determined with no clinically significant deviation from normal medical history, physical examination, electrocardiograms (ECGs), and clinical laboratory
• Women who are not of childbearing potential

Exclusion Criteria:

• Evidence of organ dysfunction or any clinically significant deviation from normal in physical examination, vital signs, ECG or clinical laboratory determinations consistent with a healthy volunteer target population
• History of clinically relevant hypoglycemic events
• History of clinically relevant hyperglycemic events