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Upper airway obstruction (UAO) is common complication during induction of general anesthesia. The mechanism of UAO during anesthesia has not been well understood. Posterior displacement of soft palate are believed to be the primary contributing factors. The mechanism of UAO during anesthesia share many similarities with obstructive sleep apnea (OSA). Since nasal continuous positive airway pressure (nCPAP) can maintain the airway patent in patients with OSA, the investigators hypothesize that nCPAP during induction of anesthesia will reduce the incidence and severity of UAO.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Nasal mask with no PEEP | Experimental | Nasal mask with PEEP 0, then add PEEP 5, and 10 |
|
| Nasal mask with PEEP | Experimental | Nasal mask with PEEP 5, then add PEEP 10 |
|
| Face mask with no PEEP | Experimental | Face mask with PEEP 0 then add PEEP 5, 10 |
|
| Face mask with PEEP | Experimental | Face mask with PEEP 5, then add PEEP 10 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| nasal mask | Procedure | nasal mask use instead of face mask |
|
| Measure | Description | Time Frame |
|---|---|---|
| expired tidal volume | Estimated time from induction of anesthesia (drugs given for anesthesia induction) to apnea is one minute. | Average of one minute after anesthesia induction |
| Measure | Description | Time Frame |
|---|---|---|
| volume of CO2 | Estimated time from induction of anesthesia (drugs given for anesthesia induction) to apnea is one minute. | Average of one minute after anesthesia induction |
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Inclusion Criteria:
Patients,between 18-65 years of age meeting ASA physical status classification I-II requiring general anesthesia for elective surgery who are able to breathe through both their nose and mouth while awake.
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Yandong Jiang, MD, PhD | Massachusetts General Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Anesthesia and Critical Care, Mass General Hospital | Boston | Massachusetts | 02114 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24365207 | Derived | Oto J, Li Q, Kimball WR, Wang J, Sabouri AS, Harrell PG, Kacmarek RM, Jiang Y. Continuous positive airway pressure and ventilation are more effective with a nasal mask than a full face mask in unconscious subjects: a randomized controlled trial. Crit Care. 2013 Dec 23;17(6):R300. doi: 10.1186/cc13169. |
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| ID | Term |
|---|---|
| D000402 | Airway Obstruction |
| ID | Term |
|---|---|
| D012131 | Respiratory Insufficiency |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
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