Mesenchymal Stromal Cells as Treatment of Chronic Graft-versus-host Disease

Mesenchymal Stromal Cells as Treatment of Chronic Graft-versus-host Disease

The aim of the study is to evaluate the safety and efficacy of mesenchymal stromal cells as treatment for steroid-refractory chronic graft-versus-host disease.

Inclusion Criteria:

• Chronic graft-versus-host disease, grade moderate or severe despite at least 3 months treatment with calcineurin inhibitors and steroids OR
• Chronic graft-versus-host disease, grade moderate or severe, where full treatment with calcineurin inhibitors and steroids is impossible due to intolerable side-effects

Exclusion Criteria:

• Active malignancy
• Fulfilling criteria for previously initiated study for treatment of chronic graft-versus-host disease