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The trial will study the acute metabolic effects of three different types of diet: low-fat diet, low-carbohydrate diet and Mediterranean diet. About 20 patients with diabetes mellitus type 2 will be recruited and each of them will be given each type of diet on three different days. Menus with the same energy content but with different content of fat, carbohydrate and protein are designed. Breakfast and lunch are served for the patients each day of testing. Laboratory samplings are performed six times during the day. The order of the dietary intervention is randomized for each patient.
The investigators suppose to find different reaction in plasma glucose and lipids depending on the type of diet.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| All test patients | Active Comparator | All test patients are given low-fat, low-carbohydrate and mediterranean diet, in randomised order on different days. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Low-fat Diet | Dietary Supplement | Low-fat Diet is provided for a breakfast and a lunch. |
|
| Measure | Description | Time Frame |
|---|---|---|
| P-glucose | mmol/l | 6 months |
| P-Triglycerides | mmol/l | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| P-Cholesterol | mmol/l | 6 months |
| P-LDL-Cholesterol | mmol/l | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Fredrik H Nystrom, Professor | Department of Endocrinology Linköping University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Medical and Health Sciences, Linköping University | Linköping | S-59183 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24312178 | Result | Fernemark H, Jaredsson C, Bunjaku B, Rosenqvist U, Nystrom FH, Guldbrand H. A randomized cross-over trial of the postprandial effects of three different diets in patients with type 2 diabetes. PLoS One. 2013 Nov 27;8(11):e79324. doi: 10.1371/journal.pone.0079324. eCollection 2013. |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D018752 | Diet, Fat-Restricted |
| D050528 | Diet, Carbohydrate-Restricted |
| D038441 | Diet, Mediterranean |
| ID | Term |
|---|---|
| D004035 | Diet Therapy |
| D044623 | Nutrition Therapy |
| D013812 | Therapeutics |
| D004032 | Diet |
| D009747 |
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| Low-carbohydrate Diet | Dietary Supplement | Low-carbohydrate Diet is provided for a breakfast and a lunch. |
|
| Mediterranean Diet | Dietary Supplement | Mediterranean Diet is provided for a breakfast and a lunch. |
|
| P-HDL-Cholesterol |
mmol/l |
| 6 months |
| D004700 | Endocrine System Diseases |
| Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D000095500 | Diet, Plant-Based |