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Subjects who are hospitalized in the ICU will be included after 24 hours of intubation during their ICU stay. Twice-daily Neuromuscular Electrical Stimulation (NMES) will be performed on one leg for 2x40 min per day to assess muscle fiber size. The investigators hypothesize an attenuated loss in muscle fiber size.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| NMES | Experimental | The 'NMES' arm will be treated with NMES. |
|
| No NMES | Sham Comparator | The 'No NMES' arm of the experiment will be sham-treated with NMES. The device will be installed, but not used. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Neuromuscular Electrical Stimulation of m. quadriceps femoris | Procedure | Neuromuscular Electrical Stimulation of m. quadriceps femoris by using a commercially available muscle stimulator |
| Measure | Description | Time Frame |
|---|---|---|
| Change in muscle fiber cross sectional area (CSA) | Muscle fiber cross sectional area (in um2) for type I and II fibers will be analyzed by using immunohistochemistry; the change of muscle fiber CSA over time will be measured | 3 hours before and 12 hours after 10 days of twice-daily NMES |
| Measure | Description | Time Frame |
|---|---|---|
| Change in upper leg circumference | Upper leg circumgerence will be measured; the change of upper leg circumference over time will be measured | 3 hours before and 12 hours after 10 days of twice-daily NMES |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jessa Hospital | Hasselt | Belgium |
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| ID | Term |
|---|---|
| D016638 | Critical Illness |
| ID | Term |
|---|---|
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D004558 | Electric Stimulation |
| ID | Term |
|---|---|
| D010812 | Physical Stimulation |
| D008919 | Investigative Techniques |
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| Sham-treatment: no NMES | Procedure | Sham comparator |
|
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