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| ID | Type | Description | Link |
|---|---|---|---|
| CEP2927/2011HUPE | Other Identifier | Ethics Committee in Research of HUPE |
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| Name | Class |
|---|---|
| Conselho Nacional de Desenvolvimento CientÃfico e Tecnológico | OTHER_GOV |
| Rio de Janeiro State Research Supporting Foundation (FAPERJ) | OTHER_GOV |
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The aim of this study is to assess the bronchodilator response of salbutamol on respiratory mechanics of healthy individuals, smokers and COPD with varying degrees of airway obstruction.
Clinical evaluation will be conducted and anthropometric measurements, then the pulmonary function tests: forced oscillation technique (FOT), whole body plethysmography, spirometry and-administration of salbutamol aerosol for assessment of bronchodilator response. After 20 minutes, the individual will be evaluated again following the same sequence.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Salbutamol | Experimental | Short-acting bronchodilator for use in humans released by the Ministry of Health, widely used worldwide for the treatment of chronic obstructive pulmonary disease. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Salbutamol sulphate | Drug | bronchodilator test, beta2-agonist, short-acting, six hours duration, 400 micrograms. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Respiratory function test | Evaluation of pulmonary mechanics before and after salbutamol (short-acting bronchodilator) in healthy individuals, smokers and chronic obstructive pulmonary disease in stages: mild, moderate, severe and very severe according to GOLD criteria. | two o'clock |
| Measure | Description | Time Frame |
|---|---|---|
| Salbutamol | In the bronchodilator test will be used 400 micrograms of beta2-agonist short-acting. They will be asked to exhale slowly until they can no longer expel more air from the lungs. To place the inhaler with a spacer between the lips, pressing them well, but no bite. Shortly thereafter start to breathe through the mouth and will be released a jet of 100 micrograms of the bronchodilator. Then they will hold their breath for 10 seconds. 3 puffs are made with 1 minute interval between each application. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Agnaldo J Lopes, PhD | Contact | 55+(21) 98536162 | phel.lop@uol.com.br | |
| Pedro L de Melo, PhD | Contact | 55+(21) 2334-0705 | plopes@uerj.br |
| Name | Affiliation | Role |
|---|---|---|
| Gerusa M Costa, MSc | State University of Rio de Janeiro | Principal Investigator |
| Pedro L Melo, PhD | Laboratory biomedical instrumentation | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Laboratory biomedical instrumentation - State University of Rio de Janeiro | Recruiting | Rio de Janeiro | Rio de Janeiro | 20550013 | Brazil |
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| Label | URL |
|---|---|
| http://www.ncbi.nlm.nih.gov/pubmed?term=gerusa%20maritimo%20da%20costa | View source |
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| ID | Term |
|---|---|
| D012907 | Smoking |
| D000402 | Airway Obstruction |
| D029424 | Pulmonary Disease, Chronic Obstructive |
| ID | Term |
|---|---|
| D001519 | Behavior |
| D012131 | Respiratory Insufficiency |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
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| ID | Term |
|---|---|
| D000420 | Albuterol |
| ID | Term |
|---|---|
| D004983 | Ethanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
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| twenty minutes |
| D008173 |
| Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D000588 |
| Amines |
| D010627 | Phenethylamines |
| D005021 | Ethylamines |