Comparison of Two Biphasic Insulin Aspart Treatments in Subjects With Type 2 Diabetes

A Randomised, Double-blind, 4-week, Crossover Trial on Two Treatment Regimens With Biphasic Insulin Aspart 70 and 50 in Patients With Type 2 Diabetes

This trial is conducted in Europe. The aim of this trial is to compare two different active treatment regimens of biphasic insulin aspart in subjects with type 2 diabetes.

Inclusion Criteria:

• Type 2 diabetes
• Duration of diabetes for longer than 12 months
• Body mass index (BMI) below 35.0 kg/m^2
• HbA1c below 11.0 %
• Treatment with BHI (biphasic human insulin) 20 or 30 twice daily for at least three months and in the last month as sole anti-diabetic treatment (i.e., no additional oral hypoglycaemic medication or daily use of short-acting insulin supplement)

Exclusion Criteria:

• Current treatment with agents affecting glucose metabolism
• History of drug or alcohol dependence
• Impaired hepatic function
• Impaired renal function
• Cardiac disease
• Proliferative retinopathy
• Recurrent severe hypoglycaemia or advanced neuropathy