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Noninvasive brain stimulations (NIBS) will be used in chronic stroke patients to improve motor learning.
Functional magnetic resonance imaging will be used to evaluate the mechanisms underlying motor learning in healthy volunteers and in chronic stroke patients.
transcranial direct current stimulation will be used for NIBS
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Real | Active Comparator | Real tDCS |
|
| sham | Placebo Comparator | Sham tDCS |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| transcranial direct current stimulation tDCS | Device | tdcs (ELDITH, Neuroconn, Ilmenau, Germany) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Motor learning improvement with tDCS | performance on a motor skill learning task and on different commonly used task (Purdue Pegboard, hand dynamometer, pinch dynamometer, 9-HPT ,...) were measured to explore the impact of tDCS on these parameters | Improvement on motor learning were recorded from baseline to 4 weeks after the intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Neuroimaging | Does cerebral mechanisms underlying motor learning differ from healthy subject to stroke patients? | before motor learning, during motor learning and after (immediately, 30,60min) motor learning (with or without tDCS) |
| Neurophysiological outcome measure |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Neurology, CHU Mont-Godinne | Yvoir | Namur | Belgium |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35311345 | Derived | Riga A, Gathy E, Ghinet M, De Laet C, Bihin B, Regnier M, Leeuwerck M, De Coene B, Dricot L, Herman B, Edwards MG, Vandermeeren Y. Evidence of Motor Skill Learning in Acute Stroke Patients Without Lesions to the Thalamus and Internal Capsule. Stroke. 2022 Jul;53(7):2361-2368. doi: 10.1161/STROKEAHA.121.035494. Epub 2022 Mar 21. | |
| 33175411 |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| D010291 | Paresis |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| D050781 | Transcranial Magnetic Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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| transcranial magnetic stimulation TMS | Device | TMS (The Magstim Company Ltd, UK) Magstim 200² with a figure-of-eight coil was used to determine the hot spot eliciting consistent movements in the contralateral hand |
|
measure of brain excitability and connectivity with TMS (single and paired pulse) |
| start of session 5min before motor learning, just at the end of the motor learning, after 30 min of motor learning, after 60 min of motor learning, Recall test at 1,2,3,4 weeks after the day of intervention (with or without tDCS) |
| Elsner B, Kugler J, Pohl M, Mehrholz J. Transcranial direct current stimulation (tDCS) for improving activities of daily living, and physical and cognitive functioning, in people after stroke. Cochrane Database Syst Rev. 2020 Nov 11;11(11):CD009645. doi: 10.1002/14651858.CD009645.pub4. |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |
| D055909 | Magnetic Field Therapy |