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The study will investigate the effectiveness of Cognitive Therapy and Acceptance and Commitment Therapy in a randomized controlled trial among patients with Major Depressive Disorder in routine clinical practice. Furthermore, the study will investigate whether each specific treatment approach is mediated by its proposed theoretical mechanism.
The current study aims at investigating the effectiveness of Cognitive Therapy and Acceptance and Commitment Therapy in a randomized controlled trial among patients with MDD in routine clinical practice. Further, the study will investigate whether each specific treatment approach is mediated by its proposed theoretical mechanism. Patients have to meet diagnostic criteria for nonpsychotic MDD as determined by the Structured Interview for DSM-IV. Each client will receive either Cognitive Therapy or Acceptance and Commitment Therapy that will last between 16 to 20 sessions. Based on previous results, it is expected that both treatment forms will prove beneficial for the patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cognitive Therapy (CT) | Experimental | Cognitive Therapy (CT) |
|
| Acceptance and Commitment Therapy (ACT) | Experimental | Acceptance and Commitment Therapy (ACT) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cognitive Therapy | Behavioral | This interventions will target: (a) behavioral dysfunction, (b) situation-specific negative thinking and cognitive distortions, and (c) underlying dysfunctional beliefs or cognitions assumed to be related to the patient's current depression and risk of future depression. A maximum of 20 45-55 minute sessions will be provided, with sessions generally held weekly for the first 8 sessions and once every two weeks for the next 8 sessions. |
| Measure | Description | Time Frame |
|---|---|---|
| QUICK INVENTORY OF DEPRESSIVE SYMPTOMATOLOGY (QIDS-SR) | Change from pre-treatment to post-treatment, 6 months follow-up and 12 months follow-up | pre-treatment, post-treatment, 6 and 12 months follow-up |
| Hamilton Rating Scale for Depression | Change from pre-treatment to post-treatment. | pre-treatment, post-treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Decentering subscale of the Experiences Questionnaire | Change between sessions and to follow-up. | Pre-treatment, in-treatment, and 6 and 12 months follow-up. |
| Acceptance and Action Questionnaire |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Paul MG Emmelkamp, PhD | University of Amsterdam | Principal Investigator |
| Nexhmedin Morina, PhD | University of Amsterdam | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| PsyQ | Zaandam | 1500 AE | Netherlands |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33446152 | Derived | A-Tjak JGL, Morina N, Topper M, Emmelkamp PMG. One year follow-up and mediation in cognitive behavioral therapy and acceptance and commitment therapy for adult depression. BMC Psychiatry. 2021 Jan 14;21(1):41. doi: 10.1186/s12888-020-03020-1. | |
| 32264845 | Derived | A-Tjak JGL, Morina N, Boendermaker WJ, Topper M, Emmelkamp PMG. Explicit and implicit attachment and the outcomes of acceptance and commitment therapy and cognitive behavioral therapy for depression. BMC Psychiatry. 2020 Apr 7;20(1):155. doi: 10.1186/s12888-020-02547-7. |
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| ID | Term |
|---|---|
| D003865 | Depressive Disorder, Major |
| ID | Term |
|---|---|
| D003866 | Depressive Disorder |
| D019964 | Mood Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D015928 | Cognitive Behavioral Therapy |
| D064869 | Acceptance and Commitment Therapy |
| ID | Term |
|---|---|
| D001521 | Behavior Therapy |
| D011613 | Psychotherapy |
| D004191 | Behavioral Disciplines and Activities |
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| Acceptance and Commitment Therapy | Behavioral | This interventions will use (a) acceptance, (b) commitment, (c) mindfulness, and (d) behavior change processes to produce reduction of depressive symptoms. A maximum of 20 45-55 minute sessions will be provided, with sessions generally held weekly for the first 8 sessions and once every two weeks for the next 8 sessions. |
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Change between sessions and to follow-up.
| Pre-treatment, in-treatment, and 6 and 12 months follow-up. |
| Dysfunctional Attitude Scale-revised | Change between sessions to follow-up. | Pre-treatment, in-treatment, and 6 and 12 months follow-up |
| Working Alliance Inventory | 3. session |
| Eurohis Quality of Life Scale | Change pre-treatment to post-treatment and to follow-up. | Pre-, post-treatment, 6 and 12 months follow-up |
| Relationship Scales | Change pre-treatment to post-treatment and to follow-up. | Pre-, post-treatment, 12 months follow-up |
| Implicit Attitude Test | Change pre-treatment to post-treatment | Pre- and posttreatment |
| Structured Clinical Interview for DSM-IV (Major Depression Module) | Change in diagnosis of Major Depression Disorder from pre-treatment to post-treatment. | Pre-treatment and post-treatment. |