Retinal Adaptation to Intensified Insulin Therapy and Bariatric Surgery in Patients With Diabetes

Retinal Adaptation to Intensified Insulin Therapy and Bariatric Surgery in Patients With Diabetes

Retinal function is highly dependent on the glucose supply. Thus, functional adaptations occur in response to both acute and long-term changes in glycaemia.

The purpose of this study is to examine functional and metabolic aspects of retinal adaptation to long-lasting changes in glycaemic control in patients with diabetes. The adaptational phenomena will be characterized by electroretinography, dark adaptation, measures of retinal perfusion and oximetry as well as diabetic retinopathy grading and (OCT).

Inclusion Criteria:

• Patients with type 1 diabetes and suboptimal metabolic regulation.
• Patients with type 2 diabetes and suboptimal metabolic regulation.

Exclusion Criteria:

• Significant cataract
• Glaucoma
• Proliferative diabetic retinopathy fulfilling ETDRS treatment criteria.
• Clinically significant macular edema fulfilling ETDRS treatment criteria.
• Age-related macular degeneration
• Prior surgery to the eye
• Other serious eye disease
• Hypertension